Tag Archives: Pollution

Washington University in St. Louis study: Air pollution contributes significantly to diabetes globally

1 Jul

Cheryl Katz wrote the 2012 Scientific American article, People in Poor Neighborhoods Breathe More Hazardous Particles:

Tiny particles of air pollution contain more hazardous ingredients in non-white and low-income communities than in affluent white ones, a new study shows.
The greater the concentration of Hispanics, Asians, African Americans or poor residents in an area, the more likely that potentially dangerous compounds such as vanadium, nitrates and zinc are in the mix of fine particles they breathe.
Latinos had the highest exposures to the largest number of these ingredients, while whites generally had the lowest.
The findings of the Yale University research add to evidence of a widening racial and economic gap when it comes to air pollution. Communities of color and those with low education and high poverty and unemployment face greater health risks even if their air quality meets federal health standards, according to the article published online in the scientific journal Environmental Health Perspectives.
Los Angeles, Pittsburgh, Cincinnati, St. Louis and Fresno are among the metropolitan areas with unhealthful levels of fine particles and large concentrations of poor minorities. More than 50 counties could exceed a new tighter health standard for particulates proposed by the Environmental Protection Agency.
Communities of color and those with low education and high poverty and unemployment may face greater health risks even if their air quality meets federal health standards. A pervasive air pollutant, the fine particulate matter known as PM2.5 is a mixture of emissions from diesel engines, power plants, refineries and other sources of combustion. Often called soot, the microscopic particles penetrate deep into the lungs.
The new study is the first to reveal major racial and economic differences in exposures to specific particle ingredients, some of which are linked to asthma, cardiovascular problems and cancer…. http://www.scientificamerican.com/article/people-poor-neighborhoods-breate-more-hazardous-particles/

A University of Miami Miller School of Medicine expanded upon the link between neighborhood greenness and disease.

Science Daily reported in Study links neighborhood greenness to reduction in chronic diseases:

A new study of a quarter-million Miami-Dade County Medicare beneficiaries showed that higher levels of neighborhood greenness, including trees, grass and other vegetation, were linked to a significant reduction in the rate of chronic illnesses, particularly in low-to-middle income neighborhoods. Led by researchers at the University of Miami Department of Public Health Sciences at the Miller School of Medicine, and the School of Architecture, the study showed that higher greenness was linked to significantly lower rates of diabetes, hypertension and high cholesterol, as well as fewer chronic health conditions.
The findings, published online April 6 by the American Journal of Preventive Medicine, are based on 2010 — 2011 health data reported for approximately 250,000 Miami-Dade Medicare beneficiaries over age 65, and a measure of vegetative presence based on NASA satellite imagery. The study was the first of its kind to examine block-level greenness and its relationship to health outcomes in older adults, and the first to measure the impact of greenness on specific cardio-metabolic diseases.
“This study builds on our research group’s earlier analyses showing block level impacts of mixed-use and supportive building features on adults and children,” said lead study author Scott Brown, Ph.D., research assistant professor of public health sciences. Brown was a co-principal investigator on the study with Elizabeth Plater-Zyberk, M.Arch., a Malcolm Matheson Distinguished Professor in Architecture. Plater-Zyberk, who was responsible for the rewrite of the City of Miami’s zoning code in 2010, said the study results “give impetus to public agencies and property owners to plant and maintain a verdant public landscape.”
Study findings revealed that higher levels of greenness on the blocks where the study’s Medicare recipients reside, is associated with a significantly lower chronic disease risk for the residents of high greenness blocks, including a 14 percent risk reduction for diabetes, a 13 percent reduction for hypertension and a 10 percent reduction for lipid disorders….. https://www.sciencedaily.com/releases/2016/04/160421171345.htm

A Washington University in St. Louis study reported a link between pollution and diabetes.

Science Daily reported in Air pollution contributes significantly to diabetes globally:

New research links outdoor air pollution — even at levels deemed safe — to an increased risk of diabetes globally, according to a study from Washington University School of Medicine in St. Louis and the Veterans Affairs (VA) St. Louis Health Care System.
The findings raise the possibility that reducing pollution may lead to a drop in diabetes cases in heavily polluted countries such as India and less polluted ones such as the United States.
Diabetes is one of the fastest growing diseases, affecting more than 420 million people worldwide and 30 million Americans. The main drivers of diabetes include eating an unhealthy diet, having a sedentary lifestyle, and obesity, but the new research indicates the extent to which outdoor air pollution plays a role.
“Our research shows a significant link between air pollution and diabetes globally,” said Ziyad Al-Aly, MD, the study’s senior author and an assistant professor of medicine at Washington University. “We found an increased risk, even at low levels of air pollution currently considered safe by the U.S. Environmental Protection Agency (EPA) and the World Health Organization (WHO). This is important because many industry lobbying groups argue that current levels are too stringent and should be relaxed. Evidence shows that current levels are still not sufficiently safe and need to be tightened.”
The findings are published June 29 in The Lancet Planetary Health.
While growing evidence has suggested a link between air pollution and diabetes, researchers have not attempted to quantify that burden until now. “Over the past two decades, there have been bits of research about diabetes and pollution,” Al-Aly said. “We wanted to thread together the pieces for a broader, more solid understanding…” https://www.sciencedaily.com/releases/2018/06/180630153740.htm

Citation:

Air pollution contributes significantly to diabetes globally
Even low pollution levels can pose health risk
Date: June 30, 2018
Source: Washington University in St. Louis
Summary:
New research links outdoor air pollution — even at levels deemed safe — to an increased risk of diabetes globally, according to a new study. The findings raise the possibility that reducing pollution may lead to a drop in diabetes cases in heavily polluted countries such as India and less polluted ones such as the United States.
Journal Reference:
1. Bowe B, Xie Y, Li T, Yan Y, Xian H, Al-Aly Z. The 2016 Global and National Burden of Diabetes Mellitus Attributable to Fine Particulate Matter Air Pollution. The Lancet Planetary Health, June 29, 2018

Here is the press release from Washington University:

PUBLIC RELEASE: 29-JUN-2018
Air pollution contributes significantly to diabetes globally
Even low pollution levels can pose health risk
WASHINGTON UNIVERSITY IN ST. LOUIS
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New research links outdoor air pollution — even at levels deemed safe — to an increased risk of diabetes globally, according to a study from Washington University School of Medicine in St. Louis and the Veterans Affairs (VA) St. Louis Health Care System.
The findings raise the possibility that reducing pollution may lead to a drop in diabetes cases in heavily polluted countries such as India and less polluted ones such as the United States.
Diabetes is one of the fastest growing diseases, affecting more than 420 million people worldwide and 30 million Americans. The main drivers of diabetes include eating an unhealthy diet, having a sedentary lifestyle, and obesity, but the new research indicates the extent to which outdoor air pollution plays a role.
“Our research shows a significant link between air pollution and diabetes globally,” said Ziyad Al-Aly, MD, the study’s senior author and an assistant professor of medicine at Washington University. “We found an increased risk, even at low levels of air pollution currently considered safe by the U.S. Environmental Protection Agency (EPA) and the World Health Organization (WHO). This is important because many industry lobbying groups argue that current levels are too stringent and should be relaxed. Evidence shows that current levels are still not sufficiently safe and need to be tightened.”
The findings are published June 29 in The Lancet Planetary Health.
While growing evidence has suggested a link between air pollution and diabetes, researchers have not attempted to quantify that burden until now. “Over the past two decades, there have been bits of research about diabetes and pollution,” Al-Aly said. “We wanted to thread together the pieces for a broader, more solid understanding.”
To evaluate outdoor air pollution, the researchers looked at particulate matter, airborne microscopic pieces of dust, dirt, smoke, soot and liquid droplets. Previous studies have found that such particles can enter the lungs and invade the bloodstream, contributing to major health conditions such as heart disease, stroke, cancer and kidney disease. In diabetes, pollution is thought to reduce insulin production and trigger inflammation, preventing the body from converting blood glucose into energy that the body needs to maintain health.
Overall, the researchers estimated that pollution contributed to 3.2 million new diabetes cases globally in 2016, which represents about 14 percent of all new diabetes cases globally that year. They also estimated that 8.2 million years of healthy life were lost in 2016 due to pollution-linked diabetes, representing about 14 percent of all years of healthy life lost due to diabetes from any cause. (The measure of how many years of healthy life are lost is often referred to as “disability-adjusted life years.”)
In the United States, the study attributed 150,000 new cases of diabetes per year to air pollution and 350,000 years of healthy life lost annually.
The Washington University team, in collaboration with scientists at the Veterans Affairs’ Clinical Epidemiology Center, examined the relationship between particulate matter and the risk of diabetes by first analyzing data from 1.7 million U.S. veterans who were followed for a median of 8.5 years. The veterans did not have histories of diabetes. The researchers linked that patient data with the EPA’s land-based air monitoring systems as well as space-borne satellites operated by the National Aeronautics and Space Administration (NASA). They used several statistical models and tested the validity against controls such as ambient air sodium concentrations, which have no link to diabetes, and lower limb fractures, which have no link to outdoor air pollution, as well as the risk of developing diabetes, which exhibited a strong link to air pollution. This exercise helped the researchers weed out spurious associations.
Then, they sifted through all research related to diabetes and outdoor air pollution and devised a model to evaluate diabetes risk across various pollution levels.
Finally, they analyzed data from the Global Burden of Disease study, which is conducted annually with contributions from researchers worldwide. The data helped to estimate annual cases of diabetes and healthy years of life lost due to pollution.
The researchers also found that the overall risk of pollution-related diabetes is tilted more toward lower-income countries such as India that lack the resources for environmental mitigation systems and clean-air policies. For instance, poverty-stricken countries facing a higher diabetes-pollution risk include Afghanistan, Papua New Guinea and Guyana, while richer countries such as France, Finland and Iceland experience a lower risk. The U.S. experiences a moderate risk of pollution-related diabetes.
In the U.S., the EPA’s pollution threshold is 12 micrograms per cubic meter of air, the highest level of air pollution considered safe for the public, as set by the Clean Air Act of 1990 and updated in 2012. However, using mathematical models, Al-Aly’s team established an increased diabetes risk at 2.4 micrograms per cubic meter of air. Based on VA data, among a sample of veterans exposed to pollution at a level of between 5 to 10 micrograms per cubic meter of air, about 21 percent developed diabetes. When that exposure increases to 11.9 to 13.6 micrograms per cubic meter of air, about 24 percent of the group developed diabetes. A 3 percent difference appears small, but it represents an increase of 5,000 to 6,000 new diabetes cases per 100,000 people in a given year.
In October 2017, The Lancet Commission on pollution and health published a report outlining knowledge gaps on pollution’s harmful health effects. One of its recommendations was to define and quantify the relationship between pollution and diabetes.
“The team in St. Louis is doing important research to firm up links between pollution and health conditions such as diabetes,” said commission member Philip J. Landrigan, MD, a pediatrician and epidemiologist who is the dean for global health at Mount Sinai School of Medicine in New York and chair of its Department of Preventive Medicine. “I believe their research will have a significant global impact.”
###
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

This society will not have healthy children without having healthy home and school environments.

A healthy child in a healthy family who attends a healthy school in a healthy neighborhood ©

Resources:

What are Key Urban Environmental Problems?
http://web.mit.edu/urbanupgrading/urbanenvironment/issues/key-UE-issues.html

Understanding Neighborhood Effects of Concentrated Poverty
https://www.huduser.gov/portal/periodicals/em/winter11/highlight2.html

Where We Live Matters for Our Health: Neighborhoods and Health
http://www.commissiononhealth.org/PDF/888f4a18-eb90-45be-a2f8-159e84a55a4c/Issue%20Brief%203%20Sept%2008%20-%20Neighborhoods%20and%20Health.pdf

Where information leads to Hope. ©

Dr. Wilda.com

Dr. Wilda says this about that ©

Blogs by Dr. Wilda:

COMMENTS FROM AN OLD FART©
http://drwildaoldfart.wordpress.com/

Dr. Wilda Reviews ©
https://drwildareviews.wordpress.com/

Dr. Wilda ©
https://drwilda.com/

University of Miami Miller School of Medicine study: Links between neighborhood greenness and reduction in chronic diseases

24 Apr

Cheryl Katz wrote the 2012 Scientific American article, People in Poor Neighborhoods Breathe More Hazardous Particles:

Tiny particles of air pollution contain more hazardous ingredients in non-white and low-income communities than in affluent white ones, a new study shows.

The greater the concentration of Hispanics, Asians, African Americans or poor residents in an area, the more likely that potentially dangerous compounds such as vanadium, nitrates and zinc are in the mix of fine particles they breathe.

Latinos had the highest exposures to the largest number of these ingredients, while whites generally had the lowest.

The findings of the Yale University research add to evidence of a widening racial and economic gap when it comes to air pollution. Communities of color and those with low education and high poverty and unemployment face greater health risks even if their air quality meets federal health standards, according to the article published online in the scientific journal Environmental Health Perspectives.

Los Angeles, Pittsburgh, Cincinnati, St. Louis and Fresno are among the metropolitan areas with unhealthful levels of fine particles and large concentrations of poor minorities. More than 50 counties could exceed a new tighter health standard for particulates proposed by the Environmental Protection Agency.

Communities of color and those with low education and high poverty and unemployment may face greater health risks even if their air quality meets federal health standards. A pervasive air pollutant, the fine particulate matter known as PM2.5 is a mixture of emissions from diesel engines, power plants, refineries and other sources of combustion. Often called soot, the microscopic particles penetrate deep into the lungs.

The new study is the first to reveal major racial and economic differences in exposures to specific particle ingredients, some of which are linked to asthma, cardiovascular problems and cancer….                                                                   http://www.scientificamerican.com/article/people-poor-neighborhoods-breate-more-hazardous-particles/

A University of Miami Miller School of Medicine expands upon the link between neighborhood greenness and disease.

Science Daily reported in Study links neighborhood greenness to reduction in chronic diseases:

A new study of a quarter-million Miami-Dade County Medicare beneficiaries showed that higher levels of neighborhood greenness, including trees, grass and other vegetation, were linked to a significant reduction in the rate of chronic illnesses, particularly in low-to-middle income neighborhoods. Led by researchers at the University of Miami Department of Public Health Sciences at the Miller School of Medicine, and the School of Architecture, the study showed that higher greenness was linked to significantly lower rates of diabetes, hypertension and high cholesterol, as well as fewer chronic health conditions.

The findings, published online April 6 by the American Journal of Preventive Medicine, are based on 2010 — 2011 health data reported for approximately 250,000 Miami-Dade Medicare beneficiaries over age 65, and a measure of vegetative presence based on NASA satellite imagery. The study was the first of its kind to examine block-level greenness and its relationship to health outcomes in older adults, and the first to measure the impact of greenness on specific cardio-metabolic diseases.

“This study builds on our research group’s earlier analyses showing block level impacts of mixed-use and supportive building features on adults and children,” said lead study author Scott Brown, Ph.D., research assistant professor of public health sciences. Brown was a co-principal investigator on the study with Elizabeth Plater-Zyberk, M.Arch., a Malcolm Matheson Distinguished Professor in Architecture. Plater-Zyberk, who was responsible for the rewrite of the City of Miami’s zoning code in 2010, said the study results “give impetus to public agencies and property owners to plant and maintain a verdant public landscape.”

Study findings revealed that higher levels of greenness on the blocks where the study’s Medicare recipients reside, is associated with a significantly lower chronic disease risk for the residents of high greenness blocks, including a 14 percent risk reduction for diabetes, a 13 percent reduction for hypertension and a 10 percent reduction for lipid disorders…..                                                   https://www.sciencedaily.com/releases/2016/04/160421171345.htm

Citation:

Study links neighborhood greenness to reduction in chronic diseases

Date:       April 21, 2016

Source:   University of Miami Miller School of Medicine

Summary:

Higher levels of greenness (trees, park space and other vegetation) in neighborhoods is linked with significantly lower chronic illnesses, diabetes, hypertension and high cholesterol, public health researchers has shown. The findings were based on 250,000 Medicare recipients age 65 and vegetation presence measured by NASA satellite imagery.

Journal Reference:

  1. Scott C. Brown, Joanna Lombard, Kefeng Wang, Margaret M. Byrne, Matthew Toro, Elizabeth Plater-Zyberk, Daniel J. Feaster, Jack Kardys, Maria I. Nardi, Gianna Perez-Gomez, Hilda M. Pantin, José Szapocznik. Neighborhood Greenness and Chronic Health Conditions in Medicare Beneficiaries. American Journal of Preventive Medicine, 2016; DOI: 10.1016/j.amepre.2016.02.008

Am J Prev Med. 2016 Mar 31. pii: S0749-3797(16)00065-9. doi: 10.1016/j.amepre.2016.02.008. [Epub ahead of print]

Neighborhood Greenness and Chronic Health Conditions in Medicare Beneficiaries.

Brown SC1, Lombard J2, Wang K3, Byrne MM3, Toro M3, Plater-Zyberk E2, Feaster DJ3, Kardys J4, Nardi MI4, Perez-Gomez G3, Pantin HM3, Szapocznik J2.

Author information

Abstract

INTRODUCTION:

Prior studies suggest that exposure to the natural environment may impact health. The present study examines the association between objective measures of block-level greenness (vegetative presence) and chronic medical conditions, including cardiometabolic conditions, in a large population-based sample of Medicare beneficiaries in Miami-Dade County, Florida.

METHODS:

The sample included 249,405 Medicare beneficiaries aged ≥65 years whose location (ZIP+4) within Miami-Dade County, Florida, did not change, from 2010 to 2011. Data were obtained in 2013 and multilevel analyses conducted in 2014 to examine relationships between greenness, measured by mean Normalized Difference Vegetation Index from satellite imagery at the Census block level, and chronic health conditions in 2011, adjusting for neighborhood median household income, individual age, gender, race, and ethnicity.

RESULTS:

Higher greenness was significantly associated with better health, adjusting for covariates: An increase in mean block-level Normalized Difference Vegetation Index from 1 SD less to 1 SD more than the mean was associated with 49 fewer chronic conditions per 1,000 individuals, which is approximately similar to a reduction in age of the overall study population by 3 years. This same level of increase in mean Normalized Difference Vegetation Index was associated with a reduced risk of diabetes by 14%, hypertension by 13%, and hyperlipidemia by 10%. Planned post-hoc analyses revealed stronger and more consistently positive relationships between greenness and health in lower- than higher-income neighborhoods.

CONCLUSIONS:

Greenness or vegetative presence may be effective in promoting health in older populations, particularly in poor neighborhoods, possibly due to increased time outdoors, physical activity, or stress mitigation.

Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:

27061891

[PubMed – as supplied by publisher]

Here is the press release from the University of Miami:

UM Study Links Neighborhood Greenness to Reduction in Chronic Diseases

Published: April 22, 2016.
Released by University of Miami Miller School of Medicine

A new study of a quarter-million Miami-Dade County Medicare beneficiaries showed that higher levels of neighborhood greenness, including trees, grass and other vegetation, were linked to a significant reduction in the rate of chronic illnesses, particularly in low-to-middle income neighborhoods. Led by researchers at the University of Miami Department of Public Health Sciences at the Miller School of Medicine, and the School of Architecture, the study showed that higher greenness was linked to significantly lower rates of diabetes, hypertension and high cholesterol, as well as fewer chronic health conditions.

The findings, published online April 6 by the American Journal of Preventive Medicine, are based on 2010 – 2011 health data reported for approximately 250,000 Miami-Dade Medicare beneficiaries over age 65, and a measure of vegetative presence based on NASA satellite imagery. The study was the first of its kind to examine block-level greenness and its relationship to health outcomes in older adults, and the first to measure the impact of greenness on specific cardio-metabolic diseases.

“This study builds on our research group’s earlier analyses showing block level impacts of mixed-use and supportive building features on adults and children,” said lead study author Scott Brown, Ph.D., research assistant professor of public health sciences. Brown was a co-principal investigator on the study with Elizabeth Plater-Zyberk, M.Arch., a Malcolm Matheson Distinguished Professor in Architecture. Plater-Zyberk, who was responsible for the rewrite of the City of Miami’s zoning code in 2010, said the study results “give impetus to public agencies and property owners to plant and maintain a verdant public landscape.”

Study findings revealed that higher levels of greenness on the blocks where the study’s Medicare recipients reside, is associated with a significantly lower chronic disease risk for the residents of high greenness blocks, including a 14 percent risk reduction for diabetes, a 13 percent reduction for hypertension and a 10 percent reduction for lipid disorders.

“Going from a low to a high level of greenness at the block level is associated with 49 fewer chronic health conditions per 1,000 residents, which is approximately equivalent to a reduction in the biomedical aging of the study population by three years,” said Brown.

Jack Kardys, Director of the Miami-Dade County Department of Parks, Recreation and Open Spaces, participated in data interpretation along with Miami-Dade County Parks’ Chief of Planning, Research, and Design Excellence, Maria Nardi. Kardys said the study findings “illuminate the vital role of parks and greens to health and well-being, and point to the critical need for a holistic approach in planning that draws on research.”

The study findings suggest extensive potential for park, open space, and streetscape design in South Florida and the United States to consider health impacts in strategic planning. Funded by the U.S. Department of Housing and Urban Development (HUD) Office of Policy Development and Research and the Health Foundation of South Florida, the research adds to a growing body of evidence that exposure to higher levels of greenness is associated with better health outcomes, by reducing stress, air pollution, humidity and heat island impacts, and encouraging physical activity, social interaction and community cohesion.

From a design standpoint, study co-author Joanna Lombard, M.Arch., professor of architecture, noted that the goals of the County’s Parks and Open Spaces Masterplan already call for residents to have access to greenspace from the minute they walk outside of their homes, through tree-lined streets, as well as greens, parks, and open spaces within a 5 to 10 minute walk of their home, all of which have been shown to be linked to better health outcomes. “There’s so much suffering involved in the time, money and energy spent on disease burden in the U.S., which we realize that we can, to some extent, ameliorate through healthy community design,” said Lombard. “We collectively need to be attentive to the health impacts of the built environment. The associated harms are evident, and most importantly going forward, the potential benefits are significant.”

In examining the results by income level and by race, the research showed that the health benefits of greenness were proportionately stronger among all racial and ethnic groups in lower income neighborhoods. Brown said this aspect of the findings suggests that incorporating more green — trees, parks and open spaces — in low income neighborhoods could also address issues of health disparities, which have been recently highlighted in research journals and the national media.

José Szapocznik, Ph.D., professor and chair of public health sciences, and founder of the University of Miami Built Environment, Behavior, and Health Research Group, pointed out that augmenting greenness, particularly in warm climates, potentially contributes to the effectiveness of other aspects of walkability. “Providing a green feature,” said Szapocznik, “has been associated with safety, increased time outdoors, physical activity, and social interaction, and may potentially reduce disease burdens at the population level and enhance residents’ quality of life.”

This society will not have healthy children without having healthy home and school environments.

A healthy child in a healthy family who attends a healthy school in a healthy neighborhood ©

Resources:

What are Key Urban Environmental Problems?                                                                     http://web.mit.edu/urbanupgrading/urbanenvironment/issues/key-UE-issues.html

Understanding Neighborhood Effects of Concentrated Poverty                                                   https://www.huduser.gov/portal/periodicals/em/winter11/highlight2.html

Where We Live Matters for Our Health: Neighborhoods and Health                                      http://www.commissiononhealth.org/PDF/888f4a18-eb90-45be-a2f8-159e84a55a4c/Issue%20Brief%203%20Sept%2008%20-%20Neighborhoods%20and%20Health.pdf

Where information leads to Hope. ©

Dr. Wilda.com

Dr. Wilda says this about that ©

Blogs by Dr. Wilda:

COMMENTS FROM AN OLD FART©

http://drwildaoldfart.wordpress.com/

Dr. Wilda Reviews ©

https://drwildareviews.wordpress.com/

Dr. Wilda ©

https://drwilda.com/

Mc Gill University study: Fathers have a profound effect on the genetics of their children

11 Oct

Benedict Carey reports in the New York Times article, Father’s Age Is Linked to Risk of Autism and Schizophrenia:

Older men are more likely than young ones to father a child who develops autism or schizophrenia, because of random mutations that become more numerous with advancing paternal age, scientists reported on Wednesday, in the first study to quantify the effect as it builds each year. The age of mothers had no bearing on the risk for these disorders, the study found.

Experts said that the finding was hardly reason to forgo fatherhood later in life, though it might have some influence on reproductive decisions. The overall risk to a man in his 40s or older is in the range of 2 percent, at most, and there are other contributing biological factors that are entirely unknown.
But the study, published online in the journal Nature, provides support for the argument that the surging rate of autism diagnoses over recent decades is attributable in part to the increasing average age of fathers, which could account for as many as 20 to 30 percent of cases.

The findings also counter the longstanding assumption that the age of the mother is the most important factor in determining the odds of a child having developmental problems. The risk of chromosomal abnormalities, like Down syndrome, increases for older mothers, but when it comes to some complex developmental and psychiatric problems, the lion’s share of the genetic risk originates in the sperm, not the egg, the study found. Previous studies had strongly suggested as much, including an analysis published in April that found that this risk was higher at age 35 than 25 and crept up with age. The new report quantifies that risk for the first time, calculating how much it accumulates each year.

The research team found that the average child born to a 20-year-old father had 25 random mutations that could be traced to paternal genetic material. The number increased steadily by two mutations a year, reaching 65 mutations for offspring of 40-year-old men.

The average number of mutations coming from the mother’s side was 15, no matter her age, the study found.

“This study provides some of the first solid scientific evidence for a true increase in the condition” of autism, said Dr. Fred R. Volkmar, director of the Child Study Center at the Yale School of Medicine, who was not involved in the research. “It is extremely well done and the sample meticulously characterized.” http://www.nytimes.com/2012/08/23/health/fathers-age-is-linked-to-risk-of-autism-and-schizophrenia.html?emc=eta1

A Mc Gill University study shows that fathers have a profound effect on the genetics of their children.

Science Daily reported in Environmental memories transmitted from a father to his grandchildren:

If you have diabetes, or cancer or even heart problems, maybe you should blame it on your dad’s behaviour or environment. Or even your grandfather’s. That’s because, in recent years, scientists have shown that, before his offspring are even conceived, a father’s life experiences involving food, drugs, exposure to toxic products and even stress can affect the development and health not only of his children, but even of his grandchildren.

But, despite a decade of work in the area, scientists haven’t been able to understand much about how this transmission of environmental memories over several generations takes place. McGill researchers and their Swiss collaborators think that they have now found a key part of the molecular puzzle. They have discovered that proteins known as histones, which have attracted relatively little attention until now, may play a crucial role in the process.

They believe that this finding, which they describe in a paper just published in Science, has the potential to profoundly change our understanding of how we inherit things. That’s because the researchers show that there is something apart from DNA that plays an important role in inheritance in general, and could determine whether a father’s children and grandchildren will be healthy or not….

There’s more than just DNA involved in inheritance

What they discovered was that there were dire consequences for the offspring both in terms of their development e.g. where offspring were prone to birth defects and had abnormal skeletal formation, and in terms of their surviving at all. Moreover, what was most surprising, was that these effects could still be seen two generations later.

“When we saw the decreased survivability across generations and the developmental abnormalities we were really blown away as it was never thought that altering something outside the DNA, i.e. a protein, could be involved in inheritance,” said Sarah Kimmins, from McGill’s Dept. of Animal Science, and one of the lead authors on the paper. Kimmins is also the Canada Research Chair in Epigenetics, Reproduction and Development.

Kimmins added, “These findings are remarkable because they indicate that information other than DNA is involved in heritability. The study highlights the critical role that fathers play in the health of their children and even grand-children. Since chemical modifications on histones are susceptible to environmental exposures, the work opens new avenues of investigation for the possible prevention and treatment of diseases of various kinds, affecting health across generations.” http://www.sciencedaily.com/releases/2015/10/151008142622.htm?utm_source=dlvr.it&utm_medium=facebook

Citation:

Environmental memories transmitted from a father to his grandchildren
Date: October 8, 2015

Source: McGill University

Summary:

If you have diabetes, or cancer or even heart problems, maybe you should blame it on your dad’s behavior or environment. Or even your grandfather’s. That’s because, in recent years, scientists have shown that, before his offspring are even conceived, a father’s life experiences involving food, drugs, exposure to toxic products and even stress can affect the development and health not only of his children, but even of his grandchildren. But, despite a decade of work in the area, scientists haven’t been able to understand much about how this transmission of environmental memories over several generations takes place. Scientists think that they have now found a key part of the molecular puzzle. They have discovered that proteins known as histones, which have attracted relatively little attention until now, may play a crucial role in the process.

Journal Reference:
1. Keith Siklenka, Serap Erkek, Maren Godmann, Romain Lambrot, Serge McGraw, Christine Lafleur, Tamara Cohen, Jianguo Xia, Matthew Suderman, Michael Hallett, Jacquetta Trasler, Antoine H. F. M. Peters, and Sarah Kimmins. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Science, 8 October 2015 DOI: 10.1126/science.aab2006

Here is the press release from Mc Gill University:

The father effect

News

If you have diabetes, or cancer or even heart problems, maybe you should blame it on your dad’s behaviour or environment. Or even your grandfather’s. That’s because, in recent years, scientists have shown that, before his offspring are even conceived, a father’s life experiences involving food, drugs, exposure to toxic products and even stress can affect the development and health not only of his children, but even of his grandchildren.

But, despite a decade of work in the area, scientists haven’t been able to understand much about how this transmission of environmental memories over several generations takes place. McGill researchers and their Swiss collaborators think that they have now found a key part of the molecular puzzle. They have discovered that proteins known as histones, which have attracted relatively little attention until now, may play a crucial role in the process.

They believe that this finding, which they describe in a paper just published in Science, has the potential to profoundly change our understanding of how we inherit things. That’s because the researchers show that there is something apart from DNA that plays an important role in inheritance in general, and could determine whether a father’s children and grandchildren will be healthy or not.

Taking a new direction

In the past, most of the research in this area, which is known as epigenetics, has focused on a process involving DNA and certain molecules (known as methyl groups) that attach to DNA and act a bit like a dimmer switch – turning up or down the expression of specific genes.

The researchers were curious about whether histones might play a role in transmitting heritable information from fathers to their offspring because they are part of the content of sperm transmitted at fertilization. Histones are distinct from our DNA, although they combine with it during cell formation, acting a bit like a spool around which the DNA winds.

So, to test their theory about the possible role of histones in guiding embryo development the researchers created mice in which they slightly altered the biochemical information on the histones during sperm cell formation and then measured the results. (It’s a bit like putting a nick in a spool of thread and seeing how it affects the way the thread then loops around the spool.) They then studied the effects on the offspring.
________________________________________
• Gestational diabetes: A diabetes predictor in fathers
• Expectant dads get depressed too
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There’s more than just DNA involved in inheritance

What they discovered was that there were dire consequences for the offspring both in terms of their development e.g. where offspring were prone to birth defects and had abnormal skeletal formation, and in terms of their surviving at all. Moreover, what was most surprising, was that these effects could still be seen two generations later.

“When we saw the decreased survivability across generations and the developmental abnormalities we were really blown away as it was never thought that altering something outside the DNA, i.e. a protein, could be involved in inheritance,” said Sarah Kimmins, from McGill’s Dept. of Animal Science, and one of the lead authors on the paper. Kimmins is also the Canada Research Chair in Epigenetics, Reproduction and Development.

Kimmins added, “These findings are remarkable because they indicate that information other than DNA is involved in heritability. The study highlights the critical role that fathers play in the health of their children and even grand-children. Since chemical modifications on histones are susceptible to environmental exposures, the work opens new avenues of investigation for the possible prevention and treatment of diseases of various kinds, affecting health across generations.”

Experts who have commented or are willing to be interviewed about the paper:
John R. McCarrey, Robert and Helen Kleberg Distinguished Chair in Cellular & Molecular Biology, Department of Biology, University of Texas at San Antonio
Prof. Marisa Bartolomei, Dept. of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania

“While there is substantial evidence that fathers can transmit diseases and adverse phenotypes to their children in the absence of genetic mutations, this is the first study that shows a feasible mechanism by which this can happen. This gives researchers confidence to pursue histone retention in the male germ cells as a mechanism of inheritance….and it also will serve as a reminder to fathers to be diligent protectors of their germline.”

The research was funded by: Canadian Institutes of Health Research (CIHR), Genome Quebec, the Reseau de Reproduction Quebecois, Fonds de recherche Nature et technologies (FRQNT), Boehringer Ingelheim Fond, Swiss National Science Foundation and the Novartis Research Foundation.

Contact Information
Contact:
Sarah Kimmins
Organization:
Dept. of Animal Science
Email:
sarah.kimmins@mcgill.ca
Secondary Contact Information
Contact:
Katherine Gombay
Organization:
Media Relations Office
Secondary Email:
katherine.gombay@mcgill.ca
Office Phone:
514-398-2189

The increased rate of poverty has profound implications if this society believes that ALL children have the right to a good basic education. Moi blogs about education issues so the reader could be perplexed sometimes because moi often writes about other things like nutrition, families, and personal responsibility issues. Why? The reader might ask? Because children will have the most success in school if they are ready to learn. Ready to learn includes proper nutrition for a healthy body and the optimum situation for children is a healthy family.

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Wayne State University study: Lead exposure in mothers can affect future generations

4 Oct

The increased rate of poverty has profound implications if this society believes that ALL children have the right to a good basic education. Moi blogs about education issues so the reader could be perplexed sometimes because moi often writes about other things like nutrition, families, and personal responsibility issues. Why? The reader might ask? Because children will have the most success in school if they are ready to learn. Ready to learn includes proper nutrition for a healthy body and the optimum situation for children is a healthy family. Many of societies’ problems would be lessened if the goal was a healthy child in a healthy family. There is a lot of economic stress in the country now because of unemployment and underemployment. Children feel the stress of their parents and they worry about how stable their family and living situation is. Sabrina Tavernise wrote an excellent New York Times article, Education Gap Grows Between Rich and Poor, Studies Say http://www.nytimes.com/2012/02/10/education/education-gap-grows-between-rich-and-poor-studies-show.html?emc=eta1 The Centers for Disease Control report:

Today at least 4 million households have children living in them that are being exposed to high levels of lead. There are approximately half a million U.S. children ages 1-5 with blood lead levels above 5 micrograms per deciliter (µg/dL), the reference level at which CDC recommends public health actions be initiated.
No safe blood lead level in children has been identified. Lead exposure can affect nearly every system in the body. Because lead exposure often occurs with no obvious symptoms, it frequently goes unrecognized. CDC’s Childhood Lead Poisoning Prevention Program is committed to the Healthy People 2020 goals of eliminating blood lead levels ≥ 10 µg/dL and differences in average risk based on race and social class as public health concerns. The program is part of the National Center for Environmental Health’s Division of Emergency and Environmental Health Services. http://www.cdc.gov/nceh/lead/

A Wayne State University study finds that lead exposure may affect more than one generation.

Science Daily reported in Lead exposure in mothers can affect future generations:

A team of researchers at Wayne State University have discovered that mothers with high levels of lead in their blood not only affect the fetal cells of their unborn children, but also their grandchildren. Their study, Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren, was published online this week in Scientific Reports.

It’s a known fact that babies in the womb can be affected by low levels of lead exposure. If a pregnant woman is exposed to lead, the lead passes through the placenta into the baby’s developing bones and other organs. Pregnant women with a past exposure to lead can also affect the unborn child’s brain, causing developmental problems later in life. Previous research studies have suggested that exposure to heavy metal toxicants can influence a person’s global DNA methylation profile….

According to Ruden, epigenetic effects of environmental exposures beyond one generation have not yet been demonstrated in humans prior to this study. He and his team tested the hypothesis that human fetal germ cell exposure to environmental toxins causes epigenetic changes in the newborn blood from a grandchild of an exposed pregnant woman.
“Our results suggest that lead exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren’s neonatal dried blood spots,” said Ruden. “This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren.”

The research team stated that this novel, two-generational study design might be able to identify the genes that may serve as possible candidate biomarkers for future transgenerational risk assessment studies…. http://www.sciencedaily.com/releases/2015/10/151002191739.htm?utm_source=dlvr.it&utm_medium=facebook

Citation:

Lead exposure in mothers can affect future generations
Date: October 2, 2015

Source: Wayne State University – Office of the Vice President for Research

Summary:
Researchers have discovered that mothers with high levels of lead in their blood not only affect the fetal cells of their unborn children, but also their grandchildren.
Journal Reference:
1. Arko Sen, Nicole Heredia, Marie-Claude Senut, Susan Land, Kurt Hollocher, Xiangyi Lu, Mary O. Dereski, Douglas M. Ruden. Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Scientific Reports, 2015; 5: 14466 DOI: 10.1038/srep14466

Here is the press release from Wayne State University:

Wayne State researchers discover evidence that lead exposure in mothers can affect future generations
October 2, 2015

DETROIT – A team of researchers at Wayne State University have discovered that mothers with high levels of lead in their blood not only affect the fetal cells of their unborn children, but also their grandchildren. Their study, Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren, was published online this week in Scientific Reports.

It’s a known fact that babies in the womb can be affected by low levels of lead exposure. If a pregnant woman is exposed to lead, the lead passes through the placenta into the baby’s developing bones and other organs. Pregnant women with a past exposure to lead can also affect the unborn child’s brain, causing developmental problems later in life. Previous research studies have suggested that exposure to heavy metal toxicants can influence a person’s global DNA methylation profile.
In the recent Wayne State study led by Douglas Ruden, Ph.D., professor in the Department of Obstetrics & Gynecology and the Institute of Environmental Health Sciences, director of epigenomics, and program leader in the Center for Urban Responses to Environmental Stressors, he and his research team revealed that lead exposure can cause specific changes in DNA methylation, which can be detected in dried blood spots beyond one generation. The neonatal blood spots from both the mothers and children in this study were obtained from the Michigan Neonatal Biobank, a unique resource that has most of the neonatal dried blood spots from children born in Michigan since 1984.

According to Ruden, epigenetic effects of environmental exposures beyond one generation have not yet been demonstrated in humans prior to this study. He and his team tested the hypothesis that human fetal germ cell exposure to environmental toxins causes epigenetic changes in the newborn blood from a grandchild of an exposed pregnant woman.
“Our results suggest that lead exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren’s neonatal dried blood spots,” said Ruden. “This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren.”

The research team stated that this novel, two-generational study design might be able to identify the genes that may serve as possible candidate biomarkers for future transgenerational risk assessment studies.
“Our pilot study provides indirect evidence that lead exposure in women during childbirth can affect the locus-specific DNA methylation status of grandchildren,” said Ruden. “However, the altered DNA methylation profiles of the grandchildren’s blood are apparently normalized during postnatal development. Also, fetal germline exposure to lead apparently has different epigenetic consequences than acute childhood exposure.”

This research was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health (R01 ES012933 and R21 ES021893) to Dr. Ruden, the WSU-NIEHS Center (P30 ES020957), and a Michigan Bloodspot Environmental Epidemiology Project (BLEEP) pilot grant from the Michigan University Research Corridor to Dr. Ruden.

Contact: Julie O’Connor
Voice: (313) 577-8845
Email: julie.oconnor@wayne.edu
Fax: (313) 577-3626
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Michael Hawthorne of the Chicago Tribune wrote about lead poisoning.

In Lead poisoning still damaging kids in poor areas, Hawthorne wrote:

One researcher working in Chicago, Anne Evens, recently published a study that draws a sharper focus on how lead is still ravaging the city years after it faded as a local and national issue.
A former chief of lead poisoning prevention at the Chicago Department of Public Health, Evens obtained the lead tests of more than 58,000 children born in the city from 1994 to 1998 and compared the results with how they performed on standardized tests in third grade.

Her peer-reviewed study, published in April in the scientific journal Environmental Health, found that exposure to lead during early childhood significantly increased the chance that a student would fail reading and math tests, even when controlling for other factors such as poverty, race, birth weight and the mother’s education level.
The scope of what Evens found is staggering: At three-quarters of Chicago Public Schools, the average lead level of third-graders exceeded a standard established by the Centers for Disease Control and Prevention in each year from 2003 to 2006….. http://www.abqjournal.com/598520/news/lead-poisoning-still-damaging-kids-in-poor-areas.html

A 2002 Journal of Public Health article, Housing and Health: Time Again for Public Health Action:

Poor housing conditions are associated with a wide range of health conditions, including respiratory infections, asthma, lead poisoning, injuries, and mental health. Addressing housing issues offers public health practitioners an opportunity to address an important social determinant of health. Public health has long been involved in housing issues. In the 19th century, health officials targeted poor sanitation, crowding, and inadequate ventilation to reduce infectious diseases as well as fire hazards to decrease injuries. Today, public health departments can employ multiple strategies to improve housing, such as developing and enforcing housing guidelines and codes, implementing “Healthy Homes” programs to improve indoor environmental quality, assessing housing conditions, and advocating for healthy, affordable housing. Now is the time for public health to create healthier homes by confronting substandard housing…. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447157/

Substandard housing has been identified as a cause of health issues for decades. The issue is what can or will be done to address the issue.

Related:

Unequal exposures: People in poor, non-white neighborhoods breathe more hazardous particles http://www.environmentalhealthnews.org/ehs/news/2012/unequal-exposures

Lead Poisoning                                                                                                                                              http://kids.niehs.nih.gov/explore/pollute/lead.htm

Learn about Lead                                                                                                                                                  http://www2.epa.gov/lead/learn-about-lead

Poor Neighborhoods’ Influence On Parents May Raise Preschool Children’s Risk Of Problems                                http://www.sciencedaily.com/releases/2008/02/080207085613.htm

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Dr. Wilda.com

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