Tag Archives: Vitamin D

Massachusetts General Hospital study: Large study confirms vitamin D does not reduce risk of depression in adults

9 Aug

Science Daily reported in Mental health issues increased significantly in young adults over last decade: Shift may be due in part to rise of digital media, study suggests:

The percentage of young Americans experiencing certain types of mental health disorders has risen significantly over the past decade, with no corresponding increase in older adults, according to research published by the American Psychological Association.
“More U.S. adolescents and young adults in the late 2010s, versus the mid-2000s, experienced serious psychological distress, major depression or suicidal thoughts, and more attempted suicide,” said lead author Jean Twenge, PhD, author of the book “iGen” and professor of psychology at San Diego State University. “These trends are weak or non-existent among adults 26 years and over, suggesting a generational shift in mood disorders instead of an overall increase across all ages.”
The research was published in the Journal of Abnormal Psychology.
Twenge and her co-authors analyzed data from the National Survey on Drug Use and Health, a nationally representative survey that has tracked drug and alcohol use, mental health and other health-related issues in individuals age 12 and over in the United States since 1971. They looked at survey responses from more than 200,000 adolescents age 12 to 17 from 2005 to 2017, and almost 400,000 adults age 18 and over from 2008 to 2017.
The rate of individuals reporting symptoms consistent with major depression in the last 12 months increased 52 percent in adolescents from 2005 to 2017 (from 8.7 percent to 13.2 percent) and 63 percent in young adults age 18 to 25 from 2009 to 2017 (from 8.1 percent to 13.2 percent). There was also a 71 percent increase in young adults experiencing serious psychological distress in the previous 30 days from 2008 to 2017 (from 7.7 percent to 13.1 percent). The rate of young adults with suicidal thoughts or other suicide-related outcomes increased 47 percent from 2008 to 2017 (from 7.0 percent to 10.3 percent).
There was no significant increase in the percentage of older adults experiencing depression or psychological distress during corresponding time periods. The researchers even saw a slight decline in psychological distress in individuals over 65.
“Cultural trends in the last 10 years may have had a larger effect on mood disorders and suicide-related outcomes among younger generations compared with older generations,” said Twenge, who believes this trend may be partially due to increased use of electronic communication and digital media, which may have changed modes of social interaction enough to affect mood disorders. She also noted research shows that young people are not sleeping as much as they did in previous generations.
The increase in digital media use may have had a bigger impact on teens and young adults because older adults’ social lives are more stable and might have changed less than teens’ social lives have in the last ten years, said Twenge. Older adults might also be less likely to use digital media in a way that interferes with sleep — for example, they might be better at not staying up late on their phones or using them in the middle of the night.
“These results suggest a need for more research to understand how digital communication versus face-to-face social interaction influences mood disorders and suicide-related outcomes and to develop specialized interventions for younger age groups,” she said….

https://www.sciencedaily.com/releases/2019/03/190315110908.ht

 

See,        https://drwilda.com/tag/mental-health/

https://drwilda.com/tag/stress-depression/

Susan M. Knight wrote in the Ethical Editor article, Large study confirms vitamin D does not reduce risk of depression in adults:

Vitamin D supplementation does not protect against depression in middle-age or older adulthood according results from one of the largest ever studies of its kind. This is a longstanding question that has likely encouraged some people to take the vitamin.

In this study, however, “There was no significant benefit from the supplement for this purpose. It did not prevent depression or improve mood,” says Olivia I. Okereke, MD, MS, of Massachusetts General Hospital (MGH’s Psychiatry Department.

Okereke is the lead author of the report and principal investigator of this study, which will be published in JAMA on Aug. 4. It included more than 18,000 men and women aged 50 years or older. Half the participants received vitamin D3 (cholecalciferol) supplementation for an average of five years, and the other half received a matching placebo for the same duration.

Vitamin D is sometimes called the “sunshine vitamin” because the skin can naturally create it when exposed to sunlight. Numerous prior studies showed that low blood levels of vitamin D (25-hydroxy vitamin D) were associated with higher risk for depression in later life, but there have been few large-scale randomized trials necessary to determine causation. Now Okereke and her colleagues have delivered what may be the definitive answer to this question.

“One scientific issue is that you actually need a very large number of study participants to tell whether or not a treatment is helping to prevent development of depression,” Okereke explains. “With nearly 20,000 people, our study was statistically powered to address this issue.”

This study, called VITAL-DEP (Depression Endpoint Prevention in the Vitamin D and Omega-3 Trial), was an ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevention among nearly 26,000 people in the US.

From that group, Okereke and her colleagues studied the 18,353 men and women who did not already have any indication of clinical depression to start with, and then tested whether vitamin D3 prevented them from becoming depressed.”

The results were clear. Among the 18,353 randomized participants, the researchers found the risk of depression or clinically relevant depressive symptoms was not significantly different between those receiving active vitamin D3 supplements and those on placebo, and there were no significant differences were seen between treatment groups in mood scores over time….                                                                                            https://www.ethicaleditor.com/health/large-study-confirms-vitamin-d-does-not-reduce-risk-of-depression-in-adults/

JAMA (2020). DOI: 10.1001/jama.2020.10224

Provided by
Massachusetts General Hospital

Citation:
Large study confirms vitamin D does not reduce risk of depression in adults (2020, August 4)
retrieved 4 August 2020
from https://medicalxpress.com/news/2020-08-large-vitamin-d-depression-adults.html

Here is the press release from Massachusetts General Hospital:

 NEWS RELEASE 4-AUG-2020

Large study confirms vitamin D does not reduce risk of depression in adults

MASSACHUSETTS GENERAL HOSPITAL

Boston – Vitamin D supplementation does not protect against depression in middle-age or older adulthood according results from one of the largest ever studies of its kind. This is a longstanding question that has likely encouraged some people to take the vitamin.

In this study, however, “There was no significant benefit from the supplement for this purpose. It did not prevent depression or improve mood,” says Olivia I. Okereke, MD, MS, of Massachusetts General Hospital (MGH’s Psychiatry Department.

Okereke is the lead author of the report and principal investigator of this study, which will be published in JAMA on Aug. 4. It included more than 18,000 men and women aged 50 years or older. Half the participants received vitamin D3 (cholecalciferol) supplementation for an average of five years, and the other half received a matching placebo for the same duration.

Vitamin D is sometimes called the “sunshine vitamin” because the skin can naturally create it when exposed to sunlight. Numerous prior studies showed that low blood levels of vitamin D (25-hydroxy vitamin D) were associated with higher risk for depression in later life, but there have been few large-scale randomized trials necessary to determine causation. Now Okereke and her colleagues have delivered what may be the definitive answer to this question.

“One scientific issue is that you actually need a very large number of study participants to tell whether or not a treatment is helping to prevent development of depression,” Okereke explains. “With nearly 20,000 people, our study was statistically powered to address this issue.”

This study, called VITAL-DEP (Depression Endpoint Prevention in the Vitamin D and Omega-3 Trial), was an ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevention among nearly 26,000 people in the US.

From that group, Okereke and her colleagues studied the 18,353 men and women who did not already have any indication of clinical depression to start with, and then tested whether vitamin D3 prevented them from becoming depressed.”

The results were clear. Among the 18,353 randomized participants, the researchers found the risk of depression or clinically relevant depressive symptoms was not significantly different between those receiving active vitamin D3 supplements and those on placebo, and there were no significant differences were seen between treatment groups in mood scores over time.

“It’s not time to throw out your vitamin D yet though, at least not without your doctor’s advice,” says Okereke. Some people take it for reasons other than to elevate mood.

“Vitamin D is known to be essential for bone and metabolic health, but randomized trials have cast doubt on many of the other presumed benefits,” said the paper’s senior author, JoAnn Manson, MD, DrPH, at Brigham and Women’s Hospital.

###

The other authors include researchers from the Psychiatry Department at UPMC and University of Pittsburgh School of Medicine, and from the VA Boston Healthcare System.”

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2020 the MGH was once again named a top hospital in the nation by U.S. News & World Report in its list of “America’s Best Hospitals.”

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

There is something to be said for Cafe Society where people actually meet face-to-face for conversation or the custom of families eating at least one meal together. Time has a good article on The Magic of the Family Meal

http://content.time.com/time/magazine/article/0,9171,1200760,00.html See, also The

Importance of Eating Together: Family dinners build relationships, and help kids do better in school.

https://www.theatlantic.com/health/archive/2014/07/the-importance-of-eating-together/374256/

It also looks like Internet rehab will have a steady supply of customers according to an article reprinted in the Seattle Times by Hillary Stout of the New York Times. In Toddlers Latch On to iPhones – and Won’t Let Go

https://www.seattletimes.com/life/lifestyle/toddlers-latch-onto-iphones-8212-and-wont-let-go/ Stout reports:

But just as adults have a hard time putting down their iPhones, so the device is now the Toy of Choice — akin to a treasured stuffed animal — for many 1-, 2- and 3-year-olds. It’s a phenomenon that is attracting the attention and concern of some childhood development specialists.

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University of Wisconsin School of Medicine and Public Health study: Vitamin D does not reduce colds in asthma patients

26 Nov

The National Heart, Lung, and Blood Institute describe asthma:

What Is Asthma?

Asthma (AZ-ma) is a chronic (long-term) lung disease that inflames and narrows the airways. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath, and coughing. The coughing often occurs at night or early in the morning.

Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 25 million people are known to have asthma. About 7 million of these people are children.

Overview

To understand asthma, it helps to know how the airways work. The airways are tubes that carry air into and out of your lungs. People who have asthma have inflamed airways. The inflammation makes the airways swollen and very sensitive. The airways tend to react strongly to certain inhaled substances.

When the airways react, the muscles around them tighten. This narrows the airways, causing less air to flow into the lungs. The swelling also can worsen, making the airways even narrower. Cells in the airways might make more mucus than usual. Mucus is a sticky, thick liquid that can further narrow the airways.

This chain reaction can result in asthma symptoms. Symptoms can happen each time the airways are inflamed….                                                                                                                                          http://www.nhlbi.nih.gov/health/health-topics/topics/asthma/

The Centers for Disease Control and Prevention describe how to tell if you have asthma:

How Can You Tell if You Have Asthma?

It can be hard to tell if someone has asthma, especially in children under age 5. Having a doctor check how well your lungs work and check for allergies can help you find out if you have asthma.

During a checkup, the doctor will ask if you cough a lot, especially at night, and whether your breathing problems are worse after physical activity or at certain times of year. The doctor will also ask about chest tightness, wheezing, and colds lasting more than 10 days. They will ask whether anyone in your family has or has had asthma, allergies, or other breathing problems, and they will ask questions about your home. The doctor will also ask if you have missed school or work and about any trouble you may have doing certain things.

The doctor will also do a breathing test, called spirometry, to find out how well your lungs are working. The doctor will use a computer with a mouthpiece to test how much air you can breathe out after taking a very deep breath. The spirometer can measure airflow before and after you use asthma medicine.

What Is an Asthma Attack?

An asthma attack may include coughing, chest tightness, wheezing, and trouble breathing. The attack happens in your body’s airways, which are the paths that carry air to your lungs. As the air moves through your lungs, the airways become smaller, like the branches of a tree are smaller than the tree trunk. During an asthma attack, the sides of the airways in your lungs swell and the airways shrink. Less air gets in and out of your lungs, and mucous that your body makes clogs up the airways even more.

You can control your asthma by knowing the warning signs of an asthma attack, staying away from things that cause an attack, and following your doctor’s advice. When you control your asthma:

  • you won’t have symptoms such as wheezing or coughing,
  • you’ll sleep better,
  • you won’t miss work or school,
  • you can take part in all physical activities, and
  • you won’t have to go to the hospital.

What Causes an Asthma Attack?

An asthma attack can happen when you are exposed to “asthma triggers”. Your triggers can be very different from those of someone else with asthma. Know your triggers and learn how to avoid them. Watch out for an attack when you can’t avoid the triggers. Some of the most common triggers are tobacco smoke, dust mites, outdoor air pollution, cockroach allergen, pets, mold, and smoke from burning wood or grass….                                                                                       http://www.cdc.gov/asthma/faqs.htm

A 2004 study by Bielory and Gandhi, Asthma and vitamin C examined “what role vitamin C may or may not play in the treatment of asthma.” They concluded:

Clearly from our review, the role of vitamin C in asthma and allergy is not well defined. The majority of the studies were short term and assessed immediate effects of vitamin C supplementation. Long term supplementation with vitamin C or delayed effects need to be studied. Although, the current literature does not support a definite indication for the use of vitamin C in asthma and allergy, the promising and positive studies revive curiosity and interest. With a large portion of health care dollars being spent on alternative medicine and vitamin C in particular, further studies are needed to define its role.

http://www.ncbi.nlm.nih.gov/pubmed/8067602

Some feel vitamin therapy is effective in treating asthma. Web MD lists studies in Vitamins & Supplements Search http://www.webmd.com/vitamins-supplements/condition-1007-Asthma.aspx?diseaseid=1007&diseasename=Asthma

Science Daily reported in Vitamin D does not reduce colds in asthma patients:

Vitamin D supplements do not reduce the number or severity of colds in asthma patients, according to a new study published online ahead of print publication in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

Loren C. Denlinger, MD, PhD, associate professor of medicine at the University of Wisconsin, and colleagues conducted a randomized, controlled trial of adults with mild-to-moderate asthma. Among African Americans in the study, those receiving supplemental vitamin D, rather than a placebo, experienced more colds.

The findings surprised the researchers who had previously published research showing a 40 percent reduction in asthma exacerbations in patients with a vitamin D deficiency who achieved normal levels of the vitamin with supplements. Because colds often trigger exacerbations, they hypothesized that vitamin D supplementation would reduce colds and cold severity.

“Other studies of vitamin D and colds have produced mixed results,” Dr. Denlinger said. “Most of those studies were conducted among healthy patients. We wanted to ask the same question of a patient population in which the impact of a cold carries greater risk.”

The researchers followed asthma patients who were undergoing inhaled corticosteroid (ICS) tapering, Denlinger added, to test the hypothesis that vitamin D might bolster the potency of the ICS.

The multi-center AsthmaNet Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness (VIDA) trial enrolled 408 adults with mild-to-moderate asthma whose vitamin D levels were insufficient or deficient (25-OH-D3 < 30 ng/mL). Those enrolled had asthma symptoms despite low-dose ICS therapy. The patients were randomized to receive either vitamin D supplementation (100,000 IU once, then 4000 IU daily) or placebo for 28 weeks. Neither the patients nor their physicians knew whether they received vitamin D or the placebo.

During that time, about half the participants experienced at least one cold. The severity of their colds was measured by the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21).

The researchers analyzed separately the results of the 82 percent of participants receiving supplements who achieved vitamin D sufficiency within 12 weeks. Achieving sufficiency made no difference in number of colds or their severity this group experienced.

The researchers wrote that one possible explanation for the unexpected finding: asthma patients with low vitamin D levels may be more likely to experience upper respiratory infections asymptomatically than those with normal levels of vitamin D, which is known to trigger an inflammatory response. This inflammatory response may, in turn, reduce the risk of lower airway infections, which are triggers for asthma exacerbations……                                                                     http://www.sciencedaily.com/releases/2015/11/151123103632.htm

Citation:

Vitamin D does not reduce colds in asthma patients

Date:         November 23, 2015

 

Source:     American Thoracic Society (ATS)

 

Summary:

Vitamin D supplements do not reduce the number or severity of colds in asthma patients, according to a new study. The findings surprised the researchers who had previously published research showing a 40 percent reduction in asthma exacerbations in patients with a vitamin D deficiency who achieved normal levels of the vitamin with supplements. Because colds often trigger exacerbations, they hypothesized that vitamin D supplementation would reduce colds and cold severity.

Journal Reference:

  1. Loren C. Denlinger, Tonya S King, Juan Carlos Cardet, Timothy Craig, Fernando Holguin, Daniel J Jackson, Monica Kraft, Stephen P Peters, Kristie Ross, Kaharu Sumino, Homer A. Boushey, Nizar N. Jarjour, Michael E Wechsler, Sally E. Wenzel, Mario Castro, Pedro C. Avila. Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. American Journal of Respiratory and Critical Care Medicine, 2015; DOI: 10.1164/rccm.201506-1169OC

Send to:

Am J Respir Crit Care Med. 2015 Nov 5. [Epub ahead of print]

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma.

Denlinger LC1, King TS2, Cardet JC3, Craig T4, Holguin F5, Jackson DJ6, Kraft M7, Peters SP8, Ross K9, Sumino K10, Boushey HA11, Jarjour NN12, Wechsler ME13, Wenzel SE14, Castro M15, Avila PC16; National Heart Lung and Blood Institute AsthmaNet Investigators.

Author information

Abstract

BACKGROUND:

Restoration of vitamin D sufficiency may reduce asthma exacerbations, events often associated with respiratory tract infections (RTIs) and cold symptoms.

OBJECTIVE:

To determine whether vitamin D supplementation reduces cold symptom occurrence and severity in adults with mild to moderate asthma and vitamin D insufficiency.

METHODS:

Colds were assessed in the AsthmaNet Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness (VIDA) trial, which randomized 408 adult patients to receive placebo or cholecalciferol (100,000 IU load plus 4,000 IU/day) for 28 weeks as add-on therapy. The primary outcome assessed cold symptom severity using daily Wisconsin Upper Respiratory Symptom Survey (WURSS)-21 scores.

RESULTS:

203 participants experienced at least one cold. Despite achieving 25-hydroxyvitamin D levels of 41.9 ng/mL (95%CI, 40.1-43.7 ng/mL) by 12 weeks, vitamin D supplementation had no effect on the primary outcome, the average peak WURSS-21 scores [62.0 (95% CI 55.1-68.9; placebo) and 58.7 (95% CI 52.4-65.0; vitamin D), p = 0.39]. The rate of colds did not differ between groups (rate ratio [RR] 1.2, 95% CI 0.9 to 1.5); however, among African-Americans those receiving vitamin D vs. placebo had an increased rate of colds (RR 1.7, 95% CI 1.1-2.7, p = 0.02). This was also observed in a responder analysis of all subjects achieving vitamin D sufficiency regardless of treatment assignment (RR 1.4, 95% CI 1.1-1.7, p = 0.009).

CONCLUSION:

In patients with mild-to-moderate asthma undergoing an ICS dose-reduction, these results do not support the use of vitamin D supplementation for the purpose of reducing cold severity or frequency. Clinical trial registration available at http://www.clinicaltrials.gov, ID NCT01248065.

KEYWORDS:

WURSS-21; asthma; upper respiratory tract infection; vitamin D

PMID:

26540136

[PubMed – as supplied by publisher]                                                                                                               http://www.ncbi.nlm.nih.gov/pubmed/26540136

The American Academy of Allergy, Asthma & Immunology (AAAAI) provides the following advice:

People with a family history of allergies or asthma are more prone to developing asthma. Many people with asthma also have allergies. This is called allergic asthma.
Occupational asthma is caused by inhaling fumes, gases, dust or other potentially harmful substances while on the job.

Childhood asthma impacts millions of children and their families. In fact, the majority of children who develop asthma do so before the age of five.

There is no cure for asthma, but once it is properly diagnosed and a treatment plan is in place you will be able to manage your condition, and your quality of life will improve.

An allergist / immunologist is the best qualified physician in diagnosing and treating asthma. With the help of your allergist, you can take control of your condition and participate in normal activities.

Keep pace with the latest information and connect with others. Join us on Facebook and Twitter.

http://www.aaaai.org/conditions-and-treatments/asthma.aspx

It is imperative to seek competent medical advice regarding individual treatment options.

Resources:

Asthma.com

http://www.asthma.com/additional-resources.html

Asthma Health Center

http://www.webmd.com/asthma/guide/asthma-support-resources

Asthma Resources

http://www.webmd.com/asthma/asthma-resources

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