Massachusetts General Hospital study: Large study confirms vitamin D does not reduce risk of depression in adults

9 Aug

Science Daily reported in Mental health issues increased significantly in young adults over last decade: Shift may be due in part to rise of digital media, study suggests:

The percentage of young Americans experiencing certain types of mental health disorders has risen significantly over the past decade, with no corresponding increase in older adults, according to research published by the American Psychological Association.
“More U.S. adolescents and young adults in the late 2010s, versus the mid-2000s, experienced serious psychological distress, major depression or suicidal thoughts, and more attempted suicide,” said lead author Jean Twenge, PhD, author of the book “iGen” and professor of psychology at San Diego State University. “These trends are weak or non-existent among adults 26 years and over, suggesting a generational shift in mood disorders instead of an overall increase across all ages.”
The research was published in the Journal of Abnormal Psychology.
Twenge and her co-authors analyzed data from the National Survey on Drug Use and Health, a nationally representative survey that has tracked drug and alcohol use, mental health and other health-related issues in individuals age 12 and over in the United States since 1971. They looked at survey responses from more than 200,000 adolescents age 12 to 17 from 2005 to 2017, and almost 400,000 adults age 18 and over from 2008 to 2017.
The rate of individuals reporting symptoms consistent with major depression in the last 12 months increased 52 percent in adolescents from 2005 to 2017 (from 8.7 percent to 13.2 percent) and 63 percent in young adults age 18 to 25 from 2009 to 2017 (from 8.1 percent to 13.2 percent). There was also a 71 percent increase in young adults experiencing serious psychological distress in the previous 30 days from 2008 to 2017 (from 7.7 percent to 13.1 percent). The rate of young adults with suicidal thoughts or other suicide-related outcomes increased 47 percent from 2008 to 2017 (from 7.0 percent to 10.3 percent).
There was no significant increase in the percentage of older adults experiencing depression or psychological distress during corresponding time periods. The researchers even saw a slight decline in psychological distress in individuals over 65.
“Cultural trends in the last 10 years may have had a larger effect on mood disorders and suicide-related outcomes among younger generations compared with older generations,” said Twenge, who believes this trend may be partially due to increased use of electronic communication and digital media, which may have changed modes of social interaction enough to affect mood disorders. She also noted research shows that young people are not sleeping as much as they did in previous generations.
The increase in digital media use may have had a bigger impact on teens and young adults because older adults’ social lives are more stable and might have changed less than teens’ social lives have in the last ten years, said Twenge. Older adults might also be less likely to use digital media in a way that interferes with sleep — for example, they might be better at not staying up late on their phones or using them in the middle of the night.
“These results suggest a need for more research to understand how digital communication versus face-to-face social interaction influences mood disorders and suicide-related outcomes and to develop specialized interventions for younger age groups,” she said….

https://www.sciencedaily.com/releases/2019/03/190315110908.ht

 

See,        https://drwilda.com/tag/mental-health/

https://drwilda.com/tag/stress-depression/

Susan M. Knight wrote in the Ethical Editor article, Large study confirms vitamin D does not reduce risk of depression in adults:

Vitamin D supplementation does not protect against depression in middle-age or older adulthood according results from one of the largest ever studies of its kind. This is a longstanding question that has likely encouraged some people to take the vitamin.

In this study, however, “There was no significant benefit from the supplement for this purpose. It did not prevent depression or improve mood,” says Olivia I. Okereke, MD, MS, of Massachusetts General Hospital (MGH’s Psychiatry Department.

Okereke is the lead author of the report and principal investigator of this study, which will be published in JAMA on Aug. 4. It included more than 18,000 men and women aged 50 years or older. Half the participants received vitamin D3 (cholecalciferol) supplementation for an average of five years, and the other half received a matching placebo for the same duration.

Vitamin D is sometimes called the “sunshine vitamin” because the skin can naturally create it when exposed to sunlight. Numerous prior studies showed that low blood levels of vitamin D (25-hydroxy vitamin D) were associated with higher risk for depression in later life, but there have been few large-scale randomized trials necessary to determine causation. Now Okereke and her colleagues have delivered what may be the definitive answer to this question.

“One scientific issue is that you actually need a very large number of study participants to tell whether or not a treatment is helping to prevent development of depression,” Okereke explains. “With nearly 20,000 people, our study was statistically powered to address this issue.”

This study, called VITAL-DEP (Depression Endpoint Prevention in the Vitamin D and Omega-3 Trial), was an ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevention among nearly 26,000 people in the US.

From that group, Okereke and her colleagues studied the 18,353 men and women who did not already have any indication of clinical depression to start with, and then tested whether vitamin D3 prevented them from becoming depressed.”

The results were clear. Among the 18,353 randomized participants, the researchers found the risk of depression or clinically relevant depressive symptoms was not significantly different between those receiving active vitamin D3 supplements and those on placebo, and there were no significant differences were seen between treatment groups in mood scores over time….                                                                                            https://www.ethicaleditor.com/health/large-study-confirms-vitamin-d-does-not-reduce-risk-of-depression-in-adults/

JAMA (2020). DOI: 10.1001/jama.2020.10224

Provided by
Massachusetts General Hospital

Citation:
Large study confirms vitamin D does not reduce risk of depression in adults (2020, August 4)
retrieved 4 August 2020
from https://medicalxpress.com/news/2020-08-large-vitamin-d-depression-adults.html

Here is the press release from Massachusetts General Hospital:

 NEWS RELEASE 4-AUG-2020

Large study confirms vitamin D does not reduce risk of depression in adults

MASSACHUSETTS GENERAL HOSPITAL

Boston – Vitamin D supplementation does not protect against depression in middle-age or older adulthood according results from one of the largest ever studies of its kind. This is a longstanding question that has likely encouraged some people to take the vitamin.

In this study, however, “There was no significant benefit from the supplement for this purpose. It did not prevent depression or improve mood,” says Olivia I. Okereke, MD, MS, of Massachusetts General Hospital (MGH’s Psychiatry Department.

Okereke is the lead author of the report and principal investigator of this study, which will be published in JAMA on Aug. 4. It included more than 18,000 men and women aged 50 years or older. Half the participants received vitamin D3 (cholecalciferol) supplementation for an average of five years, and the other half received a matching placebo for the same duration.

Vitamin D is sometimes called the “sunshine vitamin” because the skin can naturally create it when exposed to sunlight. Numerous prior studies showed that low blood levels of vitamin D (25-hydroxy vitamin D) were associated with higher risk for depression in later life, but there have been few large-scale randomized trials necessary to determine causation. Now Okereke and her colleagues have delivered what may be the definitive answer to this question.

“One scientific issue is that you actually need a very large number of study participants to tell whether or not a treatment is helping to prevent development of depression,” Okereke explains. “With nearly 20,000 people, our study was statistically powered to address this issue.”

This study, called VITAL-DEP (Depression Endpoint Prevention in the Vitamin D and Omega-3 Trial), was an ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevention among nearly 26,000 people in the US.

From that group, Okereke and her colleagues studied the 18,353 men and women who did not already have any indication of clinical depression to start with, and then tested whether vitamin D3 prevented them from becoming depressed.”

The results were clear. Among the 18,353 randomized participants, the researchers found the risk of depression or clinically relevant depressive symptoms was not significantly different between those receiving active vitamin D3 supplements and those on placebo, and there were no significant differences were seen between treatment groups in mood scores over time.

“It’s not time to throw out your vitamin D yet though, at least not without your doctor’s advice,” says Okereke. Some people take it for reasons other than to elevate mood.

“Vitamin D is known to be essential for bone and metabolic health, but randomized trials have cast doubt on many of the other presumed benefits,” said the paper’s senior author, JoAnn Manson, MD, DrPH, at Brigham and Women’s Hospital.

###

The other authors include researchers from the Psychiatry Department at UPMC and University of Pittsburgh School of Medicine, and from the VA Boston Healthcare System.”

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2020 the MGH was once again named a top hospital in the nation by U.S. News & World Report in its list of “America’s Best Hospitals.”

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

There is something to be said for Cafe Society where people actually meet face-to-face for conversation or the custom of families eating at least one meal together. Time has a good article on The Magic of the Family Meal

http://content.time.com/time/magazine/article/0,9171,1200760,00.html See, also The

Importance of Eating Together: Family dinners build relationships, and help kids do better in school.

https://www.theatlantic.com/health/archive/2014/07/the-importance-of-eating-together/374256/

It also looks like Internet rehab will have a steady supply of customers according to an article reprinted in the Seattle Times by Hillary Stout of the New York Times. In Toddlers Latch On to iPhones – and Won’t Let Go

https://www.seattletimes.com/life/lifestyle/toddlers-latch-onto-iphones-8212-and-wont-let-go/ Stout reports:

But just as adults have a hard time putting down their iPhones, so the device is now the Toy of Choice — akin to a treasured stuffed animal — for many 1-, 2- and 3-year-olds. It’s a phenomenon that is attracting the attention and concern of some childhood development specialists.

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