University of California Riverside study: America’s most widely consumed oil causes genetic changes in the brain

26 Jan

Michael Joseph gave the basics about soy bean oil in Soybean Oil: Healthy or Harmful? August 9, 2018 Last Updated on May 6, 2019:

Final Thoughts
Overall, there is a lack of direct evidence from human trials to claim that soybean oil is harmful with any certainty.
However, in my view, many studies justify being wary about the potentially detrimental effects soybean oil can have.
Especially when we consider just how much of this oil many people consume.
To summarize; soybean oil is prone to oxidation, offers predominantly omega-6 fatty acids, and has links to adverse health effects in animal studies.
With all this being said, it is probably a better idea to opt for cooking oil that does not have these concerns…. https://www.nutritionadvance.com/harmful-effects-of-soybean-oil/

Resources:

SOYBEAN OIL                                               https://www.webmd.com/vitamins/ai/ingredientmono-196/soybean-oil

Is Soybean Oil Bad for Your Health? 21 Good Reasons to Avoid https://www.authoritydiet.com/soybean-oil-bad-health-good-reasons-avoid/

Soybean Oil: One of the Most Harmful Ingredients in Processed Foods https://articles.mercola.com/sites/articles/archive/2013/01/27/soybean-oil.aspx

Science Daily reported in America’s most widely consumed oil causes genetic changes in the brain:

New UC Riverside research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer’s disease, anxiety, and depression.
Used for fast food frying, added to packaged foods, and fed to livestock, soybean oil is by far the most widely produced and consumed edible oil in the U.S., according to the U.S. Department of Agriculture. In all likelihood, it is not healthy for humans.
It certainly is not good for mice. The new study, published this month in the journal Endocrinology, compared mice fed three different diets high in fat: soybean oil, soybean oil modified to be low in linoleic acid, and coconut oil.
The same UCR research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance.
However, in the study released this month, researchers did not find any difference between the modified and unmodified soybean oil’s effects on the brain. Specifically, the scientists found pronounced effects of the oil on the hypothalamus, where a number of critical processes take place.
“The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and physical growth as well as your response to stress,” said Margarita Curras-Collazo, a UCR associate professor of neuroscience and lead author on the study.
The team determined a number of genes in mice fed soybean oil were not functioning correctly. One such gene produces the “love” hormone, oxytocin. In soybean oil-fed mice, levels of oxytocin in the hypothalamus went down.
The research team discovered roughly 100 other genes also affected by the soybean oil diet. They believe this discovery could have ramifications not just for energy metabolism, but also for proper brain function and diseases such as autism or Parkinson’s disease. However, it is important to note there is no proof the oil causes these diseases.
Additionally, the team notes the findings only apply to soybean oil — not to other soy products or to other vegetable oils.
“Do not throw out your tofu, soymilk, edamame, or soy sauce,” said Frances Sladek, a UCR toxicologist and professor of cell biology. “Many soy products only contain small amounts of the oil, and large amounts of healthful compounds such as essential fatty acids and proteins….” https://www.sciencedaily.com/releases/2020/01/200117080827.htm

Citation:

America’s most widely consumed oil causes genetic changes in the brain
Soybean oil linked to metabolic and neurological changes in mice
Date: January 17, 2020
Source: University of California – Riverside
Summary:
New research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer’s disease, anxiety, and depression.

Journal Reference:
Poonamjot Deol, Elena Kozlova, Matthew Valdez, Catherine Ho, Ei-Wen Yang, Holly Richardson, Gwendolyn Gonzalez, Edward Truong, Jack Reid, Joseph Valdez, Jonathan R Deans, Jose Martinez-Lomeli, Jane R Evans, Tao Jiang, Frances M Sladek, Margarita C Curras-Collazo. Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology, 2020; DOI: 10.1210/endocr/bqz044

Here is the press release from UC Riverside:

AUTHOR: JULES BERNSTEIN

January 17, 2020

New UC Riverside research shows soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions like autism, Alzheimer’s disease, anxiety, and depression.
Used for fast food frying, added to packaged foods, and fed to livestock, soybean oil is by far the most widely produced and consumed edible oil in the U.S., according to the U.S. Department of Agriculture. In all likelihood, it is not healthy for humans.
It certainly is not good for mice. The new study, published this month in the journal Endocrinology, compared mice fed three different diets high in fat: soybean oil, soybean oil modified to be low in linoleic acid, and coconut oil.
The same UCR research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance.
However, in the study released this month, researchers did not find any difference between the modified and unmodified soybean oil’s effects on the brain. Specifically, the scientists found pronounced effects of the oil on the hypothalamus, where a number of critical processes take place.
“The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and physical growth as well as your response to stress,” said Margarita Curras-Collazo, a UCR associate professor of neuroscience and lead author on the study.
The team determined a number of genes in mice fed soybean oil were not functioning correctly. One such gene produces the “love” hormone, oxytocin. In soybean oil-fed mice, levels of oxytocin in the hypothalamus went down.
The research team discovered roughly 100 other genes also affected by the soybean oil diet. They believe this discovery could have ramifications not just for energy metabolism, but also for proper brain function and diseases such as autism or Parkinson’s disease. However, it is important to note there is no proof the oil causes these diseases.
Additionally, the team notes the findings only apply to soybean oil — not to other soy products or to other vegetable oils.
“Do not throw out your tofu, soymilk, edamame, or soy sauce,” said Frances Sladek, a UCR toxicologist and professor of cell biology. “Many soy products only contain small amounts of the oil, and large amounts of healthful compounds such as essential fatty acids and proteins.”
A caveat for readers concerned about their most recent meal is that this study was conducted on mice, and mouse studies do not always translate to the same results in humans.
Also, this study utilized male mice. Because oxytocin is so important for maternal health and promotes mother-child bonding, similar studies need to be performed using female mice.
One additional note on this study — the research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil.
Identifying the compounds responsible for the negative effects is an important area for the team’s future research.
“This could help design healthier dietary oils in the future,” said Poonamjot Deol, an assistant project scientist in Sladek’s laboratory and first author on the study.
“The dogma is that saturated fat is bad and unsaturated fat is good. Soybean oil is a polyunsaturated fat, but the idea that it’s good for you is just not proven,” Sladek said.
Indeed, coconut oil, which contains saturated fats, produced very few changes in the hypothalamic genes.
“If there’s one message I want people to take away, it’s this: reduce consumption of soybean oil,” Deol said about the most recent study.

JULES L BERNSTEIN
Senior Public Information Officer
Email
(951) 827-4580
https://news.ucr.edu/articles/2020/01/17/americas-most-widely-consumed-oil-causes-genetic-changes-brain?_ga=2.132429064.703507897.1580080903-425658103.1580080903

Rachael Link, MS, RD wrote in Is Soybean Oil Bad for You? Benefits vs. Risks:

Benefits/Uses

1. Good Source of Vitamin K
One of the biggest soybean oil benefits is its content of vitamin K, an important micronutrient that is involved in several aspects of health. In particular, vitamin K is well-known for its ability to maintain healthy blood clotting, which can help stop excess bleeding in response to injury.
Vitamin K is also closely involved in bone health and regulating calcium stores in the bone. In fact, according to a study published in American Journal of Clinical Nutrition, lower intakes of vitamin K were associated with decreased bone mineral density in women. Plus, other studies have even found that supplementing with vitamin K could be linked to a reduced risk of bone fractures as well.
2. Promotes Heart Health
The soybean oil nutrition profile is comprised mostly of polyunsaturated fats, which are a heart-healthy type of fat found in a variety of foods such as fish, nuts and seeds.
Several studies have found that swapping out other types of fat in your diet for polyunsaturated fats could help enhance heart health. For instance, one study in PLoS Medicine showed that trading saturated fats for polyunsaturated fats in the diet significantly reduced the risk of heart disease. Other studies show that replacing saturated fats with polyunsaturated fats could also lower levels of bad LDL cholesterol, which is a major risk factor for heart disease.
Soybean oil also contains omega-3 fatty acids, which can help reduce inflammation and promote heart health as well.
3. Has a High Smoke Point
Many people prefer using soybean oil for cooking because of its high smoke point, meaning that it can withstand high temperatures without breaking down and oxidizing. In fact, the soybean oil smoke point is around 450 degrees Fahrenheit, which is significantly higher than other oils like unrefined olive, canola or flaxseed oil.
Not only can its high smoke point help optimize the flavor foods during high-heat cooking methods like baking, roasting and frying, but it can also protect against the formation of free radicals, which are harmful compounds that can contribute to chronic disease.
4. Keeps Skin Healthy
Some companies have started using soybean oil for skin care products, thanks to its ability to moisturize and soothe the skin. Interestingly enough, one small study out of Berlin showed that applying soybean oil to the skin was effective at promoting moisture retention.
Other research has found that applying it topically could protect the skin against redness and inflammation caused by UVB radiation.
5. Helps Nourish Hair
Promoting hair health is another one of the most popular soybean oil uses. In addition to helping the hair retain moisture, it can also help smooth the cuticles of the hair to keep it looking shiny. Some also use soybean oil for hair to increase the effectiveness of other products, such as hair masks and treatments.
For a simple DIY deep conditioner, try heating a few tablespoons, applying to your hair and letting it soak for 30–40 minutes before washing it out and proceeding with your normal hair care routine.

Risks and Side Effects

Although there are plenty of benefits associated with this common cooking oil, there are some soybean oil side effects and dangers that should be considered as well.
For starters, many vegetable oils on the market, including other oils like canola oil and grapeseed oil, are highly processed and refined. Opting for unrefined, minimally processed soybean oil is a better option to help maximize the potential health benefits.
Additionally, the majority of soybeans in the United States are genetically modified. Many people choose to avoid genetically modified organisms due to concerns about the long-term health effects as well as issues like antibiotic resistance and increased allergenicity. Selecting soybean oil sourced from non-GMO, organic soybeans is a good way to reduce your exposure to genetically modified organisms.
Soybean oil — like many other vegetable oils — is also high in omega-6 fatty acids. While these fatty acids are very important, the modern diet is typically very high in omega-6 fatty acids and lacking in heart-healthy omega-3s. Consuming a high amount of omega-6 fatty acids can contribute to inflammation and chronic disease over time.
Finally, keep in mind that hydrogenated soybean oil should also be avoided altogether as part of a healthy diet. These fats contain trans fats, which may be linked to a higher risk of chronic conditions such as cancer, heart disease, diabetes and more. Hydrogenated fats are often found in processed foods, such as fast food, baked goods, cookies, chips and crackers…. https://draxe.com/nutrition/soybean-oil/

For a good discussion of cooking oil, See What’s the Healthiest Oil? The Winner Is… https://universityhealthnews.com/daily/nutrition/whats-the-healthiest-oil/

Before making any dietary decisions consult a competent physician or healthcare provider.

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