Tag Archives: Brain

University of California Davis study: Curiosity changes the brain to enhance learning

6 Oct

MedicineNet.com defines working memory in the article, Definition of Working memory:

Working memory is a system for temporarily storing and managing the information required to carry out complex cognitive tasks such as learning, reasoning, and comprehension. Working memory is involved in the selection, initiation, and termination of information-processing functions such as encoding, storing, and retrieving data.
One test of working memory is memory span, the number of items, usually words or numbers, that a person can hold onto and recall. In a typical test of memory span, an examiner reads a list of random numbers aloud at about the rate of one number per second. At the end of a sequence, the person being tested is asked to recall the items in order. The average memory span for normal adults is 7 items. http://www.medterms.com/script/main/art.asp?articlekey=7143

The University of Pennsylvania researchers studied working memory in a longitudinal study. See, Penn and CHOP Researchers Track Working Memory From Childhood Through Adolescence http://www.upenn.edu/pennnews/news/penn-and-chop-researchers-track-working-memory-childhood-through-adolescence

Science Daily reported in the article, How curiosity changes the brain to enhance learning:

The more curious we are about a topic, the easier it is to learn information about that topic. New research publishing online October 2 in the Cell Press journal Neuron provides insights into what happens in our brains when curiosity is piqued. The findings could help scientists find ways to enhance overall learning and memory in both healthy individuals and those with neurological conditions.
“Our findings potentially have far-reaching implications for the public because they reveal insights into how a form of intrinsic motivation — curiosity — affects memory. These findings suggest ways to enhance learning in the classroom and other settings,” says lead author Dr. Matthias Gruber, of University of California at Davis.
For the study, participants rated their curiosity to learn the answers to a series of trivia questions. When they were later presented with a selected trivia question, there was a 14 second delay before the answer was provided, during which time the participants were shown a picture of a neutral, unrelated face. Afterwards, participants performed a surprise recognition memory test for the faces that were presented, followed by a memory test for the answers to the trivia questions. During certain parts of the study, participants had their brains scanned via functional magnetic resonance imaging.
The study revealed three major findings. First, as expected, when people were highly curious to find out the answer to a question, they were better at learning that information. More surprising, however, was that once their curiosity was aroused, they showed better learning of entirely unrelated information (face recognition) that they encountered but were not necessarily curious about. People were also better able to retain the information learned during a curious state across a 24-hour delay. “Curiosity may put the brain in a state that allows it to learn and retain any kind of information, like a vortex that sucks in what you are motivated to learn, and also everything around it,” explains Dr. Gruber.
Second, the investigators found that when curiosity is stimulated, there is increased activity in the brain circuit related to reward. “We showed that intrinsic motivation actually recruits the very same brain areas that are heavily involved in tangible, extrinsic motivation,” says Dr. Gruber. This reward circuit relies on dopamine, a chemical messenger that relays messages between neurons.
Third, the team discovered that when curiosity motivated learning, there was increased activity in the hippocampus, a brain region that is important for forming new memories, as well as increased interactions between the hippocampus and the reward circuit. “So curiosity recruits the reward system, and interactions between the reward system and the hippocampus seem to put the brain in a state in which you are more likely to learn and retain information, even if that information is not of particular interest or importance,” explains principal investigator Dr. Charan Ranganath, also of UC Davis.
The findings could have implications for medicine and beyond. For example, the brain circuits that rely on dopamine tend to decline in function as people get older, or sooner in people with neurological conditions. Understanding the relationship between motivation and memory could therefore stimulate new efforts to improve memory in the healthy elderly and to develop new approaches for treating patients with disorders that affect memory. And in the classroom or workplace, learning what might be considered boring material could be enhanced if teachers or managers are able to harness the power of students’ and workers’ curiosity about something they are naturally motivated to learn.
http://www.sciencedaily.com/releases/2014/10/141002123631.htm

Citation:

How curiosity changes the brain to enhance learning
Date: October 2, 2014
Source: Cell Press
Summary:
The more curious we are about a topic, the easier it is to learn information about that topic. New research provides insights into what happens in our brains when curiosity is piqued. The findings could help scientists find ways to enhance overall learning and memory in both healthy individuals and those with neurological conditions.
States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit
Matthias J. Gruber ,
Bernard D. Gelman,
Charan Ranganath
DOI: http://dx.doi.org/10.1016/j.neuron.2014.08.060
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect.
Highlights
• •People are better at learning information that they are curious about
• •Memory for incidental material presented during curious states was also enhanced
• •Curiosity associated with anticipatory activity in nucleus accumbens and midbrain
• •Memory benefits for incidental material depend on midbrain-hippocampus involvement
Summary
People find it easier to learn about topics that interest them, but little is known about the mechanisms by which intrinsic motivational states affect learning. We used functional magnetic resonance imaging to investigate how curiosity (intrinsic motivation to learn) influences memory. In both immediate and one-day-delayed memory tests, participants showed improved memory for information that they were curious about and for incidental material learned during states of high curiosity. Functional magnetic resonance imaging results revealed that activity in the midbrain and the nucleus accumbens was enhanced during
states of high curiosity. Importantly, individual variability in curiosity-driven memory benefits for incidental material was supported by anticipatory activity in the midbrain and hippocampus and by functional connectivity between these regions. These findings suggest a link between the mechanisms supporting extrinsic reward motivation and intrinsic curiosity and highlight the importance of stimulating curiosity to create more effective learning experiences.

Here is the press release from Cell Press Journal:

PUBLIC RELEASE DATE:
2-Oct-2014
Contact: Mary Beth O’Leary
moleary@cell.com
617-397-2802
Cell Press
@CellPressNews
How curiosity changes the brain to enhance learning
The more curious we are about a topic, the easier it is to learn information about that topic. New research publishing online October 2 in the Cell Press journal Neuron provides insights into what happens in our brains when curiosity is piqued. The findings could help scientists find ways to enhance overall learning and memory in both healthy individuals and those with neurological conditions.
“Our findings potentially have far-reaching implications for the public because they reveal insights into how a form of intrinsic motivation—curiosity—affects memory. These findings suggest ways to enhance learning in the classroom and other settings,” says lead author Dr. Matthias Gruber, of University of California at Davis.
For the study, participants rated their curiosity to learn the answers to a series of trivia questions. When they were later presented with a selected trivia question, there was a 14 second delay before the answer was provided, during which time the participants were shown a picture of a neutral, unrelated face. Afterwards, participants performed a surprise recognition memory test for the faces that were presented, followed by a memory test for the answers to the trivia questions. During certain parts of the study, participants had their brains scanned via functional magnetic resonance imaging.
The study revealed three major findings. First, as expected, when people were highly curious to find out the answer to a question, they were better at learning that information. More surprising, however, was that once their curiosity was aroused, they showed better learning of entirely unrelated information (face recognition) that they encountered but were not necessarily curious about. People were also better able to retain the information learned during a curious state across a 24-hour delay. “Curiosity may put the brain in a state that allows it to learn and retain any kind of information, like a vortex that sucks in what you are motivated to learn, and also everything around it,” explains Dr. Gruber.
Second, the investigators found that when curiosity is stimulated, there is increased activity in the brain circuit related to reward. “We showed that intrinsic motivation actually recruits the very same brain areas that are heavily involved in tangible, extrinsic motivation,” says Dr. Gruber. This reward circuit relies on dopamine, a chemical messenger that relays messages between neurons.
Third, the team discovered that when curiosity motivated learning, there was increased activity in the hippocampus, a brain region that is important for forming new memories, as well as increased interactions between the hippocampus and the reward circuit. “So curiosity recruits the reward system, and interactions between the reward system and the hippocampus seem to put the brain in a state in which you are more likely to learn and retain information, even if that information is not of particular interest or importance,” explains principal investigator Dr. Charan Ranganath, also of UC Davis.
The findings could have implications for medicine and beyond. For example, the brain circuits that rely on dopamine tend to decline in function as people get older, or sooner in people with neurological conditions. Understanding the relationship between motivation and memory could therefore stimulate new efforts to improve memory in the healthy elderly and to develop new approaches for treating patients with disorders that affect memory. And in the classroom or workplace, learning what might be considered boring material could be enhanced if teachers or managers are able to harness the power of students’ and workers’ curiosity about something they are naturally motivated to learn.
###
Neuron, Gruber et al.: “States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit.”

Parents can help foster curious kids.

Justin Coulson writes in the article, Raising smart, curious children:

Parents can do several things that will foster curiosity and a love of learning in their children, and help them grow up intellectually stimulated and successful.
• Model a love of learning. Be seen reading, finding answers, and discovering things yourself. Your children will watch and learn from you.
• Embrace the motto “we try new things”. Whether it is a new meal, a new sport, a new holiday destination, or a new way of cleaning the house, let your children know that you want to try new things and discover things you previously did not know much about.
• Teach your children to find answers. When your children ask you a question, rather than answering them directly encourage them to find out for themselves. Point them to references, the Internet, or other useful sources.
• Ask questions. If your child is curious about something, find out why. Encourage discussion. Find out what s/he knows already. When your child makes a statement (about anything) you can ask “why” and have an interesting conversation. Your demonstration of curiosity can be a terrific example to your children
• Be willing to talk. It is often easy for a parent to say “I’ll tell you later”, or “Not now, I’m busy.” Such responses will dampen the enthusiasm and curiosity a child has for a subject. Be being available, your child will be able to pursue a love of learning and all you have to do is facilitate it.
• Provide tools for learning by visiting the library, buying books from the shops, and having access to the Internet available for appropriate learning activities.
• Eliminate the use of rewards for learning. Research shows that the more we reward someone for a task, the less interested they become in the task. When rewards are offered, people generally become more interested in the reward than in the process required to obtain the reward. Instead, encourage curiosity for its own sake….. http://www.kidspot.com.au/schoolzone/Study-tips-Raising-smart-curious-children+4165+304+article.htm

Education is a partnership and parents must help educators foster curiosity in children.

The important thing is not to stop questioning. Curiosity has its own reason for existing.
Albert Einstein

Resources:

How Can Teachers Foster Curiosity? http://www.edweek.org/ew/articles/2014/06/04/33shonstrom.h33.html

How to Stimulate Curiosity http://ideas.time.com/2013/04/15/how-to-stimulate-curiosity/

Six ways to build greater curiosity in students http://edge.ascd.org/blogpost/six-ways-to-build-greater-curiosity-in-students

How to Ignite Intellectual Curiosity in Students http://www.edutopia.org/blog/igniting-student-curiousity-inquiry-method

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University of Texas Center for Brain Health study: The brains of risk-taking teens are different

17 Aug

We live in a society with few personal controls and even fewer people recognize boundaries which should govern their behavior and how they treat others. Many parents want tips about how to talk with their kids about risky behaviors and whether they should spy on their children.
Perhaps the best advice comes from Carleton Kendrick in the Family Education article, Spying on Kids

Staying connected
So how do you make sure your teens are on the straight and narrow? You can’t. And don’t think you can forbid them to experiment with risky behavior. That’s what they’re good at during this stage, along with testing your limits. You can help them stay healthy, safe, and secure by doing the following:
• Keep communicating with your teens, even if they don’t seem to be listening. Talk about topics that interest them.
• Respect and ask their opinions.
• Give them privacy. That doesn’t mean you can’t knock on their door when you want to talk.
• Set limits on their behavior based on your values and principles. They will grudgingly respect you for this.
• Continually tell them and show them you believe in who they are rather than what they accomplish.
• Seek professional help if your teen’s abnormal behaviors last more than three weeks.
A 1997 landmark adolescent health study, which interviewed over 12,000 teenagers, concluded that the single greatest protection against high-risk teenage behavior, like substance abuse and suicide, is a strong emotional connection to a parent. Tough as it may be, you should always try to connect with them. And leave the spying to James Bond. It will only drive away the children you wish to bring closer.

In truth, a close relationship with your child will probably be more effective than spying. Put down that Blackberry, iPhone, and Droid and try connecting with your child. You should not only know who your children’s friends are, but you should know the parents of your children’s friends. Many parents have the house where all the kids hang out because they want to know what is going on with their kids. Often parents volunteer to chauffeur kids because that gives them the opportunity to listen to what kids are talking about. It is important to know the values of the families of your kid’s friends. Do they furnish liquor to underage kids, for example? How do they feel about teen sex and is their house the place where kids meet for sex? Lisa Frederiksen has written the excellent article, 10 Tips for Talking to Teens About Sex, Drugs & Alcohol http://www.drugfree.org/10-tips-for-talking-to-teens-about-sex-drugs-alcohol/ which was posted at the Partnership for Drug-Free Kids http://www.drugfree.org/
According to a Center for Brain Health study, some teens are more prone to risky behavior than others because of differences in their brains.

Science Digest reported in the article, Brain imaging shows brain differences in risk-taking teens:

According to the CDC, unintentional injuries are the leading cause of death for adolescents. Compared to the two leading causes of death for all Americans, heart disease and cancer, a pattern of questionable decision-making in dire situations comes to light in teen mortality. New research from the Center for BrainHealth at The University of Texas at Dallas investigating brain differences associated with risk-taking teens found that connections between certain brain regions are amplified in teens more prone to risk.
“Our brains have an emotional-regulation network that exists to govern emotions and influence decision-making,” explained the study’s lead author, Sam Dewitt. “Antisocial or risk-seeking behavior may be associated with an imbalance in this network.”
The study, published June 30 in Psychiatry Research: Neuroimaging, looked at 36 adolescents ages 12-17; eighteen risk-taking teens were age- and sex-matched to a group of 18 non-risk-taking teens. Participants were screened for risk-taking behaviors, such as drug and alcohol use, sexual promiscuity, and physical violence and underwent functional MRI (fMRI) scans to examine communication between brain regions associated with the emotional-regulation network. Interestingly, the risk-taking group showed significantly lower income compared to the non-risk taking group.
“Most fMRI scans used to be done in conjunction with a particular visual task. In the past several years, however, it has been shown that performing an fMRI scan of the brain during a ‘mind-wandering’ state is just as valuable,”said Sina Aslan, Ph.D., President of Advance MRI and Adjunct Assistant Professor at the Center for BrainHealth at The University of Texas at Dallas.”In this case, brain regions associated with emotion and reward centers show increased connection even when they are not explicitly engaged.”
The study, conducted by Francesca Filbey, Ph.D., Director of Cognitive Neuroscience Research of Addictive Behaviors at the Center for BrainHealth and her colleagues, shows that risk-taking teens exhibit hyperconnectivity between the amygdala, a center responsible for emotional reactivity, and specific areas of the prefrontal cortex associated with emotion regulation and critical thinking skills. The researchers also found increased activity between areas of the prefrontal cortex and the nucleus accumbens, a center for reward sensitivity that is often implicated in addiction research….
http://www.sciencedaily.com/releases/2014/08/140815102326.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news%2Ftop_science+%28ScienceDaily%3A+Top+Science+News%29&utm_content=FaceBook

Citation:

Brain imaging shows brain differences in risk-taking teens
Date: August 15, 2014

Source: Center for BrainHealth
Summary:
Brain differences associated with risk-taking teens have been investigated by researchers who found that connections between certain brain regions are amplified in teens more prone to risk. “Our brains have an emotional-regulation network that exists to govern emotions and influence decision-making,” explained the study’s lead author. “Antisocial or risk-seeking behavior may be associated with an imbalance in this network.”
Here is the blog post from the Center for Brain Health:
Study: Brain imaging shows brain differences in risk-taking teens
By: The Center for BrainHealth
Thursday, August 14, 2014
According to the CDC, unintentional injuries are the leading cause of death for adolescents. Compared to the two leading causes of death for all Americans, heart disease and cancer, a pattern of questionable decision-making in dire situations comes to light in teen mortality. New research from the Center for BrainHealth at The University of Texas at Dallas investigating brain differences associated with risk-taking teens found that connections between certain brain regions are amplified in teens more prone to risk.
“Our brains have an emotional-regulation network that exists to govern emotions and influence decision-making,” explained the study’s lead author, Sam Dewitt. “Antisocial or risk-seeking behavior may be associated with an imbalance in this network.”
The study, published June 30 in Psychiatry Research: Neuroimaging, looked at 36 adolescents ages 12-17; eighteen risk-taking teens were age- and sex-matched to a group of 18 non-risk-taking teens. Participants were screened for risk-taking behaviors, such as drug and alcohol use, sexual promiscuity, and physical violence and underwent functional MRI (fMRI) scans to examine communication between brain regions associated with the emotional-regulation network. Interestingly, the risk-taking group showed significantly lower income compared to the non-risk taking group.
“Most fMRI scans used to be done in conjunction with a particular visual task. In the past several years, however, it has been shown that performing an fMRI scan of the brain during a ‘mind-wandering’ state is just as valuable,”said Sina Aslan, Ph.D., President of Advance MRI and Adjunct Assistant Professor at the Center for BrainHealth at The University of Texas at Dallas.“In this case, brain regions associated with emotion and reward centers show increased connection even when they are not explicitly engaged.”
The study, conducted by Francesca Filbey, Ph.D., Director of Cognitive Neuroscience Research of Addictive Behaviors at the Center for BrainHealth and her colleagues, shows that risk-taking teens exhibit hyperconnectivity between the amygdala, a center responsible for emotional reactivity, and specific areas of the prefrontal cortex associated with emotion regulation and critical thinking skills. The researchers also found increased activity between areas of the prefrontal cortex and the nucleus accumbens, a center for reward sensitivity that is often implicated in addiction research.
“Our findings are crucial in that they help identify potential brain biomarkers that, when taken into context with behavioral differences, may help identify which adolescents are at risk for dangerous and pathological behaviors in the future,” Dewitt explained.
He also points out that even though the risk-taking group did partake in risky behavior, none met clinical criteria for behavioral or substance use disorders.
By identifying these factors early on, the research team hopes to have a better chance of providing effective cognitive strategies to help risk-seeking adolescents regulate their emotions and avoid risk-taking behavior and substance abuse. http://www.brainhealth.utdallas.edu/blog_page/study-brain-imaging-shows-brain-differences-in-risk-taking-teens

So, in answer to the question should you spy on your Kids? Depends on the child. Some children are more susceptible to peer pressure and impulsive behavior than others. They will require more and possibly more intrusive direction. Others really are free range children and have the resources and judgment to make good decisions in a variety of circumstances. Even within a family there will be different needs and abilities. The difficulty for parents is to make the appropriate judgments and still give each child the feeling that they have been treated fairly. Still, for some kids, it is not out of line for parents to be snoops, they just might save the child and themselves a lot of heartache.

Resources:

Sexting Information: What every parent should know about sexting.
http://www.noslang.com/sexting.php

Social Networking and Internet Safety Information for Parents: Sexting
http://internet-safety.yoursphere.com/sexting/

Teen Sexting Tips
http://www.safeteens.com/teen-sexting-tips/

Related:

New study about ‘sexting’ and teens
https://drwilda.wordpress.com/2011/12/05/new-study-about-sexting-and-teens/

Sexting’ during school hours

Sexting’ during school hours

Children and swearing
https://drwilda.wordpress.com/2012/04/29/children-and-swearing/

Does what is worn in school matter?
https://drwilda.wordpress.com/2012/04/02/does-what-is-worn-in-school-matter/

Teen dating violence on the rise
https://drwilda.wordpress.com/2012/04/01/teen-dating-violence-on-the-rise/

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Johns Hopkins study: Education mitigates the effects of brain injury

24 Apr

Education Portal defines illiteracy in the article, Illiteracy: The Downfall of American Society.

Most people think of literacy as a simple question of being able to read. But while a young child who can work her way through a basic picture book is considered to have age-appropriate literacy levels, an adult who can only read at the most fundamental level is still functionally illiterate.
The world requires that adults not only be able to read and understand basic texts, but also be able to function in the workplace, pay bills, understand legal and financial documents and navigate technology – not to mention the advanced reading comprehension skills required to pursue postsecondary education and the opportunities that come with it.
As a result, when we talk about the effects of illiteracy on society, we’re talking primarily about what happens when you have a large number of adults whose literacy skills are too low to perform normal, day-to-day tasks. However, it is worth keeping in mind that childhood illiteracy is, of course, directly correlated to adult illiteracy. http://education-portal.com/articles/Illiteracy_The_Downfall_of_American_Society.html

The key concept is the individual cannot adequately function in the society in which they live. That means that tasks necessary to provide a satisfactory life are difficult because they cannot read and/or comprehend what they read.
Research is taking the concept of literacy a step farther with the concept of cognitive reserve.

Jon Hamilton of NPR reported in the article, Education May Help Insulate The Brain Against Traumatic Injury:

A little education goes a long way toward ensuring you’ll recover from a serious traumatic brain injury. In fact, people with lots of education are seven times more likely than high school dropouts to have no measurable disability a year later.
“It’s a very dramatic difference,” says Eric Schneider, an epidemiologist at Johns Hopkins and the lead author of a new study. The finding suggests that people with more education have brains that are better able to “find ways around the damage” caused by an injury, he says.
The study looked at the medical records of 769 adults who suffered traumatic brain injuries serious enough to require an inpatient hospital stay and rehabilitation. A year after the injury, just 10 percent of people who didn’t finish high school had no disability, compared with 39 percent of people with enough years of education to have received a college degree. People with advanced degrees did even better.
One reason for the difference may be something known as “cognitive reserve” in the brain, Schneider says. The concept is a bit like physical fitness, he says, which can help a person recover from a physical injury. Similarly, a person with a lot of cognitive reserve may be better equipped to recover from a brain injury…
For several decades, studies have shown that people with more education, and presumably more cognitive reserve, are less likely to develop the memory and thinking problems of Alzheimer’s disease. The new study suggests the benefits of education and cognitive reserve extend to brain damage caused by injury rather than disease.
There’s no guaranteed way to increase your cognitive reserve, Schneider says. But there are hints that staying physically and socially active helps, and that “pursuing lifelong learning may be beneficial,” he says.
One limitation of the study is that it relied on a standard disability rating scale, which relies on measures such as a person’s ability to return to work. That could have meant that a college graduate returning to an office job was less likely to be declared disabled than, “a roofer with balance issues,” Schneider says. He adds that even people with a disability rating of zero may still have mental or physical problems caused by their brain injury. http://www.npr.org/blogs/health/2014/04/23/306228476/education-may-help-insulate-the-brain-against-traumatic-injury

Citation:

Functional recovery after moderate/severe traumatic brain injury
A role for cognitive reserve?
1. Eric B. Schneider, PhD,
2. Sandeepa Sur, MSc, MHS,
3. Vanessa Raymont, MBChB, MSc, MRCPsych,
4. Josh Duckworth, MD,
5. Robert G. Kowalski, MBBCh, MS,
6. David T. Efron, MD,
7. Xuan Hui, MD, ScM,
8. Shalini Selvarajah, MD, MPH,
9. Hali L. Hambridge, ScM and
10. Robert D. Stevens, MD
+SHOW AFFILIATIONS
| + SHOW FULL DISCLOSURES
1. From the Center for Surgical Trials and Outcomes Research, Department of Surgery (E.B.S., D.T.E., X.H., S. Selvarajah, H.L.H.), Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine (R.G.K., R.D.S.), and Departments of Neurology (R.D.S.) and Neurosurgery (R.D.S.), Johns Hopkins School of Medicine, Baltimore, MD; Tulane Center for Aging (S. Sur), Tulane University School of Medicine, New Orleans, LA; Department of Radiology (V.R., J.D., R.D.S.), Johns Hopkins University, Baltimore, MD; and Centre for Mental Health (V.R.), Department of Medicine, Imperial College London, UK.
1. Correspondence to Dr. Schneider: eschnei1@jhmi.edu
+ AUTHOR DISCLOSURES: ERIC B. SCHNEIDER, PHD
+ AUTHOR DISCLOSURES: SANDEEPA SUR, MSC, MHS
+ AUTHOR DISCLOSURES: VANESSA RAYMONT, MBCHB, MSC, MRCPSYCH
+ AUTHOR DISCLOSURES: JOSH DUCKWORTH, MD
+ AUTHOR DISCLOSURES: ROBERT G. KOWALSKI, MBBCH, MS
+ AUTHOR DISCLOSURES: DAVID T. EFRON, MD
+ AUTHOR DISCLOSURES: XUAN HUI, MD, SCM
+ AUTHOR DISCLOSURES: SHALINI SELVARAJAH, MD, MPH
+ AUTHOR DISCLOSURES: HALI L. HAMBRIDGE, SCM
+ AUTHOR DISCLOSURES: ROBERT D. STEVENS, MD
1. Published online before print April 23, 2014, doi: 10.1212/WNL.0000000000000379 Neurology 10.1212/WNL.0000000000000379
» Abstract
Full Text (PDF)
1. Also available:
2. Accompanying Comment
Abstract
Objective: To evaluate the hypothesis that educational attainment, a marker of cognitive reserve, is a predictor of disability-free recovery (DFR) after moderate to severe traumatic brain injury (TBI).
Methods: Retrospective study of the TBI Model Systems Database, a prospective multicenter cohort funded by the National Institute on Disability and Rehabilitation Research. Patients were included if they were admitted for rehabilitation after moderate to severe TBI, were aged 23 years or older, and had at least 1 year of follow-up. The main outcome measure was DFR 1 year postinjury, defined as a Disability Rating Scale score of zero.
Results: Of 769 patients included, 214 (27.8%) achieved DFR at 1 year. In total, 185 patients (24.1%) had <12 years of education, while 390 (50.7%) and 194 patients (25.2%) had 12 to 15 years and ≥16 years of education, respectively. DFR was achieved by 18 patients (9.7%) with <12 years, 120 (30.8%) with 12 to 15 years, and 76 (39.2%) with ≥16 years of education (p < 0.001). In a logistic regression model controlling for age, sex, and injury- and rehabilitation-specific factors, duration of education of ≥12 years was independently associated with DFR (odds ratio 4.74, 95% confidence interval 2.70–8.32 for 12–15 years; odds ratio 7.24, 95% confidence interval 3.96–13.23 for ≥16 years).
Conclusion: Educational attainment was a robust independent predictor of 1-year DFR even when adjusting for other prognostic factors. A dose-response relationship was noted, with longer educational exposure associated with increased odds of DFR. This suggests that cognitive reserve could be a factor driving neural adaptation during recovery from TBI.
Received July 18, 2013.
Accepted in final form January 21, 2014.
© 2014 American Academy of Neurology

Cognitive reserve is the key concept in interpreting this study.

Molly Edmonds wrote in the How Stuff Works article, Can you delay dementia?

But don’t get downhearted; even if you didn’t go for that Ph.D., you can still start challenging the brain at any age to build up cognitive reserve. Software and video games meant to challenge the brain have begun popping up on the market, though scientists warn that these tools don’t have much science behind them [sources: Belluck, Larson]. You don’t even have to get that high-tech. In one study, participants who worked a crossword puzzle four days of the week had a 47 percent lower risk of dementia than those who did a crossword once a week . Mental activities like playing chess and other board games, learning a foreign language, volunteering, reading and playing a musical instrument all keep the brain humming. Finding a friend to do some of these activities with is also a bonus — in a study that examined over 1,000 people, those with a limited social network were 60 percent more likely to have dementia after a three-year period .
For a real-life example of how cognitive reserve can delay dementia, look no further than the 678 Catholic Sisters of Notre Dame, of Mankato, Minn. These nuns’ cognitive states were studied for years as doctors tried to learn more about dementia, and doctors conducted postmortem exams on the women’s brains. In one examination, doctors found that some of the nuns who had signs of Alzheimer’s disease in the brain hadn’t demonstrated a lack of cognitive function while still alive. The doctors did notice that the blood vessels in the brain were in exceptionally good shape, however, meaning that even as Alzheimer’s started to appear, the brain found a way to work around the challenges [sources: Whitehouse, Tan]. That’s not to say that cognitive reserve can delay dementia forever — if the women had lived longer, they may have developed dementia eventually.
Your brain depends on a regular flow of blood, so another way to keep those cerebral blood vessels working well is good old-fashioned exercise. Read on to find out what other physical activities can help your brain. http://health.howstuffworks.com/mental-health/dementia/delay-dementia1.htm

Just as one must exercise their body to stay healthy, they must also exercise their brain.

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